Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study

It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients w...

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Autores principales: Williams, E.J., Mair, L., de Silva, T.I., Green, D.J., House, P., Cawthron, K., Gillies, C., Wigfull, J., Parsons, H., Partridge, D.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of The Healthcare Infection Society. 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817391/
https://www.ncbi.nlm.nih.gov/pubmed/33484783
http://dx.doi.org/10.1016/j.jhin.2021.01.006
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author Williams, E.J.
Mair, L.
de Silva, T.I.
Green, D.J.
House, P.
Cawthron, K.
Gillies, C.
Wigfull, J.
Parsons, H.
Partridge, D.G.
author_facet Williams, E.J.
Mair, L.
de Silva, T.I.
Green, D.J.
House, P.
Cawthron, K.
Gillies, C.
Wigfull, J.
Parsons, H.
Partridge, D.G.
author_sort Williams, E.J.
collection PubMed
description It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.
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spelling pubmed-78173912021-01-21 Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study Williams, E.J. Mair, L. de Silva, T.I. Green, D.J. House, P. Cawthron, K. Gillies, C. Wigfull, J. Parsons, H. Partridge, D.G. J Hosp Infect Short Report It can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. 2021-04 2021-01-20 /pmc/articles/PMC7817391/ /pubmed/33484783 http://dx.doi.org/10.1016/j.jhin.2021.01.006 Text en Crown Copyright © 2021 Published by Elsevier Ltd on behalf of The Healthcare Infection Society. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Report
Williams, E.J.
Mair, L.
de Silva, T.I.
Green, D.J.
House, P.
Cawthron, K.
Gillies, C.
Wigfull, J.
Parsons, H.
Partridge, D.G.
Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study
title Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study
title_full Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study
title_fullStr Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study
title_full_unstemmed Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study
title_short Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study
title_sort evaluation of procalcitonin as a contribution to antimicrobial stewardship in sars-cov-2 infection: a retrospective cohort study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817391/
https://www.ncbi.nlm.nih.gov/pubmed/33484783
http://dx.doi.org/10.1016/j.jhin.2021.01.006
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