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A compartmental epidemic model incorporating probable cases to model COVID-19 outbreak in regions with limited testing capacity

We propose a new compartmental epidemic model taking into account people who have symptoms with no confirmatory laboratory testing (probable cases). We prove well-posedness of the model and provide an explicit expression for the basic reproduction number ([Formula: see text]). We use the model toget...

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Detalles Bibliográficos
Autores principales: Hasan, A., Nasution, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ISA. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817488/
https://www.ncbi.nlm.nih.gov/pubmed/33487398
http://dx.doi.org/10.1016/j.isatra.2021.01.029
Descripción
Sumario:We propose a new compartmental epidemic model taking into account people who have symptoms with no confirmatory laboratory testing (probable cases). We prove well-posedness of the model and provide an explicit expression for the basic reproduction number ([Formula: see text]). We use the model together with an extended Kalman filter (EKF) to estimate the time-varying effective reproduction number ([Formula: see text]) of COVID-19 in West Java province in Indonesia and the state of Michigan in the USA, where laboratory testing capacities are limited. Based on our estimation, the value of [Formula: see text] is higher when the probable cases are taken into account. This correction can be used by decision and policy makers when considering re-opening policy and evaluation of public measures.