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Anti-Influenza virus effects of Enterococcus faecalis KH2 and Lactobacillus plantarum SNK12 RNA
Bacterial RNA has recently emerged as an immune-stimulating factor during viral infection. The immune response in an organism is directly related to the progression of virus infections. Lactic acid bacteria in particular have anticancer, bioprotective, and antiallergic effects by modulating immunity...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMFH Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817512/ https://www.ncbi.nlm.nih.gov/pubmed/33520568 http://dx.doi.org/10.12938/bmfh.2020-019 |
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author | WATANABE, Takumi HAYASHI, Kyoko KAN, Tatsuhiko OHWAKI, Makoto KAWAHARA, Toshio |
author_facet | WATANABE, Takumi HAYASHI, Kyoko KAN, Tatsuhiko OHWAKI, Makoto KAWAHARA, Toshio |
author_sort | WATANABE, Takumi |
collection | PubMed |
description | Bacterial RNA has recently emerged as an immune-stimulating factor during viral infection. The immune response in an organism is directly related to the progression of virus infections. Lactic acid bacteria in particular have anticancer, bioprotective, and antiallergic effects by modulating immunity. Here, we aimed to demonstrate the effect of bacterial RNA on in vitro production of IL-12, a proinflammatory cytokine, and on in vivo activity against influenza A virus (IFV) infection. Oral administration of heat-killed Enterococcus faecalis KH2 (KH2) or Lactobacillus plantarum SNK12 (SNK) in IFV-infected mice suppressed viral replication and stimulated production of virus-specific antibodies. However, ribonuclease-treated KH2 or SNK abrogated the effect, reducing IL-12 production in vitro and anti-IFV effects in vivo. Taken together, KH2 or SNK showed antiviral effects in vivo when administered orally, and the RNAs of KH2 and SNK play a part in these effects, despite the phylogenetic differences between the bacteria. |
format | Online Article Text |
id | pubmed-7817512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMFH Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78175122021-01-28 Anti-Influenza virus effects of Enterococcus faecalis KH2 and Lactobacillus plantarum SNK12 RNA WATANABE, Takumi HAYASHI, Kyoko KAN, Tatsuhiko OHWAKI, Makoto KAWAHARA, Toshio Biosci Microbiota Food Health Full Paper Bacterial RNA has recently emerged as an immune-stimulating factor during viral infection. The immune response in an organism is directly related to the progression of virus infections. Lactic acid bacteria in particular have anticancer, bioprotective, and antiallergic effects by modulating immunity. Here, we aimed to demonstrate the effect of bacterial RNA on in vitro production of IL-12, a proinflammatory cytokine, and on in vivo activity against influenza A virus (IFV) infection. Oral administration of heat-killed Enterococcus faecalis KH2 (KH2) or Lactobacillus plantarum SNK12 (SNK) in IFV-infected mice suppressed viral replication and stimulated production of virus-specific antibodies. However, ribonuclease-treated KH2 or SNK abrogated the effect, reducing IL-12 production in vitro and anti-IFV effects in vivo. Taken together, KH2 or SNK showed antiviral effects in vivo when administered orally, and the RNAs of KH2 and SNK play a part in these effects, despite the phylogenetic differences between the bacteria. BMFH Press 2020-09-12 2021 /pmc/articles/PMC7817512/ /pubmed/33520568 http://dx.doi.org/10.12938/bmfh.2020-019 Text en ©2021 BMFH Press This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Full Paper WATANABE, Takumi HAYASHI, Kyoko KAN, Tatsuhiko OHWAKI, Makoto KAWAHARA, Toshio Anti-Influenza virus effects of Enterococcus faecalis KH2 and Lactobacillus plantarum SNK12 RNA |
title | Anti-Influenza virus effects of Enterococcus faecalis KH2
and Lactobacillus plantarum SNK12 RNA |
title_full | Anti-Influenza virus effects of Enterococcus faecalis KH2
and Lactobacillus plantarum SNK12 RNA |
title_fullStr | Anti-Influenza virus effects of Enterococcus faecalis KH2
and Lactobacillus plantarum SNK12 RNA |
title_full_unstemmed | Anti-Influenza virus effects of Enterococcus faecalis KH2
and Lactobacillus plantarum SNK12 RNA |
title_short | Anti-Influenza virus effects of Enterococcus faecalis KH2
and Lactobacillus plantarum SNK12 RNA |
title_sort | anti-influenza virus effects of enterococcus faecalis kh2
and lactobacillus plantarum snk12 rna |
topic | Full Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817512/ https://www.ncbi.nlm.nih.gov/pubmed/33520568 http://dx.doi.org/10.12938/bmfh.2020-019 |
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