Severe Hypokalemia Secondary to Transient Distal Renal Tubular Acidosis in a Previously Healthy Woman

Normal anion gap (non-gap) hyperchloremic acidosis with hypokalemia is a medical emergency. There are several causes of this metabolic phenomenon, of which distal renal tubular acidosis is among the very rare causes. In this report, we present an unusual case of a previously healthy woman who was admitted to the intensive care unit with a short history of severe muscle weakness. She had no significant past medical history and was not taking any regular medication. There was also no history of recent drug or herb ingestion. Investigations demonstrated a combination of severe hypokalemia, hyperchloremia, hypobicarbonatemia (non-gap metabolic acidosis), and relatively raised urinary potassium and urinary pH in the presence of severe hypokalemia and metabolic acidosis. Results suggested a diagnosis of distal renal tubular acidosis. The patient responded rapidly to a short course of electrolyte replacement therapy and the condition resolved spontaneously thereafter. This case highlights the fact that distal renal tubular acidosis can occur as a transient phenomenon in previously healthy individuals.