Letermovir for the compassionate therapeutic use of cytomegalovirus infection

PURPOSE: Data on the efficacy, dosing and safety of letermovir for the compassionate therapeutic use of CMV infections are limited. METHODS: Clinical and virological efficacy of letermovir was assessed in a retrospective single-centre study of patients who received letermovir for the compassionate t...

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Autores principales: Schubert, Lorenz, Fisecker, Lisa, Thalhammer, Florian, Burgmann, Heinz, Steininger, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817558/
https://www.ncbi.nlm.nih.gov/pubmed/32914220
http://dx.doi.org/10.1007/s10096-020-03990-w
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author Schubert, Lorenz
Fisecker, Lisa
Thalhammer, Florian
Burgmann, Heinz
Steininger, Christoph
author_facet Schubert, Lorenz
Fisecker, Lisa
Thalhammer, Florian
Burgmann, Heinz
Steininger, Christoph
author_sort Schubert, Lorenz
collection PubMed
description PURPOSE: Data on the efficacy, dosing and safety of letermovir for the compassionate therapeutic use of CMV infections are limited. METHODS: Clinical and virological efficacy of letermovir was assessed in a retrospective single-centre study of patients who received letermovir for the compassionate therapeutic use of CMV infections. RESULTS: Letermovir initiation yielded prompt treatment response in 7 out of 9 patients (77.7%). CONCLUSION: Letermovir may be an effective and well tolerated option in the compassionate treatment of CMV infections, although recurrence of CMV and emergence of resistance may be issues.
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spelling pubmed-78175582021-01-25 Letermovir for the compassionate therapeutic use of cytomegalovirus infection Schubert, Lorenz Fisecker, Lisa Thalhammer, Florian Burgmann, Heinz Steininger, Christoph Eur J Clin Microbiol Infect Dis Brief Report PURPOSE: Data on the efficacy, dosing and safety of letermovir for the compassionate therapeutic use of CMV infections are limited. METHODS: Clinical and virological efficacy of letermovir was assessed in a retrospective single-centre study of patients who received letermovir for the compassionate therapeutic use of CMV infections. RESULTS: Letermovir initiation yielded prompt treatment response in 7 out of 9 patients (77.7%). CONCLUSION: Letermovir may be an effective and well tolerated option in the compassionate treatment of CMV infections, although recurrence of CMV and emergence of resistance may be issues. Springer Berlin Heidelberg 2020-09-11 2021 /pmc/articles/PMC7817558/ /pubmed/32914220 http://dx.doi.org/10.1007/s10096-020-03990-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Report
Schubert, Lorenz
Fisecker, Lisa
Thalhammer, Florian
Burgmann, Heinz
Steininger, Christoph
Letermovir for the compassionate therapeutic use of cytomegalovirus infection
title Letermovir for the compassionate therapeutic use of cytomegalovirus infection
title_full Letermovir for the compassionate therapeutic use of cytomegalovirus infection
title_fullStr Letermovir for the compassionate therapeutic use of cytomegalovirus infection
title_full_unstemmed Letermovir for the compassionate therapeutic use of cytomegalovirus infection
title_short Letermovir for the compassionate therapeutic use of cytomegalovirus infection
title_sort letermovir for the compassionate therapeutic use of cytomegalovirus infection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817558/
https://www.ncbi.nlm.nih.gov/pubmed/32914220
http://dx.doi.org/10.1007/s10096-020-03990-w
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