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The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells

Targeted DNA correction of disease-causing mutations in hematopoietic stem and progenitor cells (HSPCs) may enable the treatment of genetic diseases of the blood and immune system. It is now possible to correct mutations at high frequencies in HSPCs by combining CRISPR/Cas9 with homologous DNA donor...

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Detalles Bibliográficos
Autores principales:	Sharma, Rajiv, Dever, Daniel P., Lee, Ciaran M., Azizi, Armon, Pan, Yidan, Camarena, Joab, Köhnke, Thomas, Bao, Gang, Porteus, Matthew H., Majeti, Ravindra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817666/ https://www.ncbi.nlm.nih.gov/pubmed/33473139 http://dx.doi.org/10.1038/s41467-020-20792-y

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