The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus maturation, dysregulation of host inflammation, and antiviral immune responses. The multiple functions of PLpro render it a p...

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Detalles Bibliográficos
Autores principales: Fu, Ziyang, Huang, Bin, Tang, Jinle, Liu, Shuyan, Liu, Ming, Ye, Yuxin, Liu, Zhihong, Xiong, Yuxian, Zhu, Wenning, Cao, Dan, Li, Jihui, Niu, Xiaogang, Zhou, Huan, Zhao, Yong Juan, Zhang, Guoliang, Huang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817691/
https://www.ncbi.nlm.nih.gov/pubmed/33473130
http://dx.doi.org/10.1038/s41467-020-20718-8

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