Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates

The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate decisions (e.g., cell cycle arrest, apoptosis). Foundational to this process is the binding of tetrameric p53 to 20-bp response elements (REs) in...

Descripción completa

Detalles Bibliográficos
Autores principales: Farkas, Marina, Hashimoto, Hideharu, Bi, Yingtao, Davuluri, Ramana V., Resnick-Silverman, Lois, Manfredi, James J., Debler, Erik W., McMahon, Steven B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817693/
https://www.ncbi.nlm.nih.gov/pubmed/33473123
http://dx.doi.org/10.1038/s41467-020-20783-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817693/
https://www.ncbi.nlm.nih.gov/pubmed/33473123
http://dx.doi.org/10.1038/s41467-020-20783-z

Ejemplares similares