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Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease
Peripheral artery disease is caused by atherosclerosis of lower extremity arteries leading to the loss of blood perfusion and subsequent critical ischemia. The presence of diabetes mellitus is an important risk factor that greatly increases the incidence, the progression and the severity of the dise...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817696/ https://www.ncbi.nlm.nih.gov/pubmed/33490120 http://dx.doi.org/10.3389/fcvm.2020.619612 |
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author | Mercier, Clément Rousseau, Marina Geraldes, Pedro |
author_facet | Mercier, Clément Rousseau, Marina Geraldes, Pedro |
author_sort | Mercier, Clément |
collection | PubMed |
description | Peripheral artery disease is caused by atherosclerosis of lower extremity arteries leading to the loss of blood perfusion and subsequent critical ischemia. The presence of diabetes mellitus is an important risk factor that greatly increases the incidence, the progression and the severity of the disease. In addition to accelerated disease progression, diabetic patients are also more susceptible to develop serious impairment of their walking abilities through an increased risk of lower limb amputation. Hyperglycemia is known to alter the physiological development of collateral arteries in response to ischemia. Deregulation in the production of several critical pro-angiogenic factors has been reported in diabetes along with vascular cell unresponsiveness in initiating angiogenic processes. Among the multiple molecular mechanisms involved in the angiogenic response, protein tyrosine phosphatases are potent regulators by dephosphorylating pro-angiogenic tyrosine kinase receptors. However, evidence has indicated that diabetes-induced deregulation of phosphatases contributes to the progression of several micro and macrovascular complications. This review provides an overview of growth factor alterations in the context of diabetes and peripheral artery disease, as well as a description of the role of phosphatases in the regulation of angiogenic pathways followed by an analysis of the effects of hyperglycemia on the modulation of protein tyrosine phosphatase expression and activity. Knowledge of the role of phosphatases in diabetic peripheral artery disease will help the development of future therapeutics to locally regulate phosphatases and improve angiogenesis. |
format | Online Article Text |
id | pubmed-7817696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78176962021-01-22 Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease Mercier, Clément Rousseau, Marina Geraldes, Pedro Front Cardiovasc Med Cardiovascular Medicine Peripheral artery disease is caused by atherosclerosis of lower extremity arteries leading to the loss of blood perfusion and subsequent critical ischemia. The presence of diabetes mellitus is an important risk factor that greatly increases the incidence, the progression and the severity of the disease. In addition to accelerated disease progression, diabetic patients are also more susceptible to develop serious impairment of their walking abilities through an increased risk of lower limb amputation. Hyperglycemia is known to alter the physiological development of collateral arteries in response to ischemia. Deregulation in the production of several critical pro-angiogenic factors has been reported in diabetes along with vascular cell unresponsiveness in initiating angiogenic processes. Among the multiple molecular mechanisms involved in the angiogenic response, protein tyrosine phosphatases are potent regulators by dephosphorylating pro-angiogenic tyrosine kinase receptors. However, evidence has indicated that diabetes-induced deregulation of phosphatases contributes to the progression of several micro and macrovascular complications. This review provides an overview of growth factor alterations in the context of diabetes and peripheral artery disease, as well as a description of the role of phosphatases in the regulation of angiogenic pathways followed by an analysis of the effects of hyperglycemia on the modulation of protein tyrosine phosphatase expression and activity. Knowledge of the role of phosphatases in diabetic peripheral artery disease will help the development of future therapeutics to locally regulate phosphatases and improve angiogenesis. Frontiers Media S.A. 2021-01-07 /pmc/articles/PMC7817696/ /pubmed/33490120 http://dx.doi.org/10.3389/fcvm.2020.619612 Text en Copyright © 2021 Mercier, Rousseau and Geraldes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Mercier, Clément Rousseau, Marina Geraldes, Pedro Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease |
title | Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease |
title_full | Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease |
title_fullStr | Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease |
title_full_unstemmed | Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease |
title_short | Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease |
title_sort | growth factor deregulation and emerging role of phosphatases in diabetic peripheral artery disease |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817696/ https://www.ncbi.nlm.nih.gov/pubmed/33490120 http://dx.doi.org/10.3389/fcvm.2020.619612 |
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