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A quadratic function of activation in individuals at risk of Alzheimer's disease
INTRODUCTION: Brain activation is hypothesized to form an inverse U‐shape in prodromal Alzheimer's disease (AD), with hyperactivation in the early phase, followed by hypoactivation. METHODS: Using task‐related functional magnetic resonance imaging (fMRI), we tested the inverse U‐shape hypothesi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817778/ https://www.ncbi.nlm.nih.gov/pubmed/33521234 http://dx.doi.org/10.1002/dad2.12139 |
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author | Corriveau‐Lecavalier, Nick Duchesne, Simon Gauthier, Serge Hudon, Carol Kergoat, Marie‐Jeanne Mellah, Samira Belleville, Sylvie |
author_facet | Corriveau‐Lecavalier, Nick Duchesne, Simon Gauthier, Serge Hudon, Carol Kergoat, Marie‐Jeanne Mellah, Samira Belleville, Sylvie |
author_sort | Corriveau‐Lecavalier, Nick |
collection | PubMed |
description | INTRODUCTION: Brain activation is hypothesized to form an inverse U‐shape in prodromal Alzheimer's disease (AD), with hyperactivation in the early phase, followed by hypoactivation. METHODS: Using task‐related functional magnetic resonance imaging (fMRI), we tested the inverse U‐shape hypothesis with polynomial regressions and between‐group comparisons in individuals with subjective cognitive decline plus (SCD(+); smaller hippocampal volumes compared to a group of healthy controls without SCD and/or apolipoprotein E [APOE] ε4 allele) or mild cognitive impairment (MCI). RESULTS: A quadratic function modeled the relationship between proxies of disease severity (neurodegeneration, memory performance) and left superior parietal activation. Linear negative functions modeled the relationship between neurodegeneration and left hippocampal/right inferior temporal activation. Group comparison indicated presence of hyperactivation in SCD(+) and hypoactivation in MCI in the left superior parietal lobule, relative to healthy controls. DISCUSSION: These findings support the presence of an inverse U‐shape model of activation and suggest that hyperactivation might represent a biomarker of the early AD stages. |
format | Online Article Text |
id | pubmed-7817778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78177782021-01-29 A quadratic function of activation in individuals at risk of Alzheimer's disease Corriveau‐Lecavalier, Nick Duchesne, Simon Gauthier, Serge Hudon, Carol Kergoat, Marie‐Jeanne Mellah, Samira Belleville, Sylvie Alzheimers Dement (Amst) Cognitive & Behavioral Assessment INTRODUCTION: Brain activation is hypothesized to form an inverse U‐shape in prodromal Alzheimer's disease (AD), with hyperactivation in the early phase, followed by hypoactivation. METHODS: Using task‐related functional magnetic resonance imaging (fMRI), we tested the inverse U‐shape hypothesis with polynomial regressions and between‐group comparisons in individuals with subjective cognitive decline plus (SCD(+); smaller hippocampal volumes compared to a group of healthy controls without SCD and/or apolipoprotein E [APOE] ε4 allele) or mild cognitive impairment (MCI). RESULTS: A quadratic function modeled the relationship between proxies of disease severity (neurodegeneration, memory performance) and left superior parietal activation. Linear negative functions modeled the relationship between neurodegeneration and left hippocampal/right inferior temporal activation. Group comparison indicated presence of hyperactivation in SCD(+) and hypoactivation in MCI in the left superior parietal lobule, relative to healthy controls. DISCUSSION: These findings support the presence of an inverse U‐shape model of activation and suggest that hyperactivation might represent a biomarker of the early AD stages. John Wiley and Sons Inc. 2021-01-20 /pmc/articles/PMC7817778/ /pubmed/33521234 http://dx.doi.org/10.1002/dad2.12139 Text en © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Cognitive & Behavioral Assessment Corriveau‐Lecavalier, Nick Duchesne, Simon Gauthier, Serge Hudon, Carol Kergoat, Marie‐Jeanne Mellah, Samira Belleville, Sylvie A quadratic function of activation in individuals at risk of Alzheimer's disease |
title | A quadratic function of activation in individuals at risk of Alzheimer's disease |
title_full | A quadratic function of activation in individuals at risk of Alzheimer's disease |
title_fullStr | A quadratic function of activation in individuals at risk of Alzheimer's disease |
title_full_unstemmed | A quadratic function of activation in individuals at risk of Alzheimer's disease |
title_short | A quadratic function of activation in individuals at risk of Alzheimer's disease |
title_sort | quadratic function of activation in individuals at risk of alzheimer's disease |
topic | Cognitive & Behavioral Assessment |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817778/ https://www.ncbi.nlm.nih.gov/pubmed/33521234 http://dx.doi.org/10.1002/dad2.12139 |
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