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Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases
Background: Ewing sarcoma is the second most common malignant bone tumor in children, but it rarely originates from extra-skeletal sites. The commonly involved sites of soft tissue include paravertebral spaces, lower extremities, the pelvis, head, and neck, while primary extra-skeletal Ewing sarcoma...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817810/ https://www.ncbi.nlm.nih.gov/pubmed/33489999 http://dx.doi.org/10.3389/fped.2020.591257 |
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author | Zheng, Chuanxi Zhou, Yong Luo, Yi Zhang, Hongying Tu, Chongqi Min, Li |
author_facet | Zheng, Chuanxi Zhou, Yong Luo, Yi Zhang, Hongying Tu, Chongqi Min, Li |
author_sort | Zheng, Chuanxi |
collection | PubMed |
description | Background: Ewing sarcoma is the second most common malignant bone tumor in children, but it rarely originates from extra-skeletal sites. The commonly involved sites of soft tissue include paravertebral spaces, lower extremities, the pelvis, head, and neck, while primary extra-skeletal Ewing sarcoma (EES) located in the genitals is extremely rare. Case Presentation: We report a young patient who presented to our hospital with a painful erection of the penis and limited motion of the left hip. Magnetic resonance imaging showed a hyperintense mass with invasion of adjacent tissue in the penis and a heterogeneously high signal lesion in the left proximal femur. (18)F-fluorodeoxyglucose positron-emission tomography detected widespread metastatic lesions in the bilateral lung and multiple skeletons. An incisional biopsy of the penis was performed; the histopathological findings and EWS gene translocation identified by molecular analysis confirmed the diagnosis of Ewing sarcoma. Subsequently, the punch-biopsy specimen from the left femur showed undifferentiated small round cells, a finding consistent with the microscopic presence of Ewing sarcoma metastasis. However, after the first course of multiagent chemotherapy, the penile mass did not obtain stabilization but instead grew progressively with surface ulceration and multidrug resistant bacteria infection. Despite receiving antibiotics and maximal supportive therapy, the patient died from sepsis and lung metastasis complications in the intensive care unit 2 months later. Conclusion: This case indicates that although EES as a subtype of Ewing sarcoma is rare, it can occur virtually in any soft tissue site, even in the genitals. Therefore, clinicians need to distinguish this entity from other soft tissue sarcomas with rapid progression since early diagnosis and timely treatment of EES are pivotal for a favorable prognosis. |
format | Online Article Text |
id | pubmed-7817810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78178102021-01-22 Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases Zheng, Chuanxi Zhou, Yong Luo, Yi Zhang, Hongying Tu, Chongqi Min, Li Front Pediatr Pediatrics Background: Ewing sarcoma is the second most common malignant bone tumor in children, but it rarely originates from extra-skeletal sites. The commonly involved sites of soft tissue include paravertebral spaces, lower extremities, the pelvis, head, and neck, while primary extra-skeletal Ewing sarcoma (EES) located in the genitals is extremely rare. Case Presentation: We report a young patient who presented to our hospital with a painful erection of the penis and limited motion of the left hip. Magnetic resonance imaging showed a hyperintense mass with invasion of adjacent tissue in the penis and a heterogeneously high signal lesion in the left proximal femur. (18)F-fluorodeoxyglucose positron-emission tomography detected widespread metastatic lesions in the bilateral lung and multiple skeletons. An incisional biopsy of the penis was performed; the histopathological findings and EWS gene translocation identified by molecular analysis confirmed the diagnosis of Ewing sarcoma. Subsequently, the punch-biopsy specimen from the left femur showed undifferentiated small round cells, a finding consistent with the microscopic presence of Ewing sarcoma metastasis. However, after the first course of multiagent chemotherapy, the penile mass did not obtain stabilization but instead grew progressively with surface ulceration and multidrug resistant bacteria infection. Despite receiving antibiotics and maximal supportive therapy, the patient died from sepsis and lung metastasis complications in the intensive care unit 2 months later. Conclusion: This case indicates that although EES as a subtype of Ewing sarcoma is rare, it can occur virtually in any soft tissue site, even in the genitals. Therefore, clinicians need to distinguish this entity from other soft tissue sarcomas with rapid progression since early diagnosis and timely treatment of EES are pivotal for a favorable prognosis. Frontiers Media S.A. 2021-01-07 /pmc/articles/PMC7817810/ /pubmed/33489999 http://dx.doi.org/10.3389/fped.2020.591257 Text en Copyright © 2021 Zheng, Zhou, Luo, Zhang, Tu and Min. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Zheng, Chuanxi Zhou, Yong Luo, Yi Zhang, Hongying Tu, Chongqi Min, Li Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases |
title | Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases |
title_full | Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases |
title_fullStr | Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases |
title_full_unstemmed | Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases |
title_short | Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases |
title_sort | case report: primary ewing sarcoma of the penis with multiple metastases |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817810/ https://www.ncbi.nlm.nih.gov/pubmed/33489999 http://dx.doi.org/10.3389/fped.2020.591257 |
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