Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

Endonuclease G (ENDOG), a mitochondrial nuclease, is known to participate in many cellular processes, including apoptosis and paternal mitochondrial elimination, while its role in autophagy remains unclear. Here, we report that ENDOG released from mitochondria promotes autophagy during starvation, w...

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Detalles Bibliográficos
Autores principales: Wang, Wenjun, Li, Jianshuang, Tan, Junyang, Wang, Miaomiao, Yang, Jing, Zhang, Zhi-Min, Li, Chuanzhou, Basnakian, Alexei G., Tang, Hong-Wen, Perrimon, Norbert, Zhou, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817833/
https://www.ncbi.nlm.nih.gov/pubmed/33473107
http://dx.doi.org/10.1038/s41467-020-20780-2

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