Cargando…

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

T helper type 17 (Th17) cells have important functions in the pathogenesis of inflammatory and autoimmune diseases. Retinoid-related orphan receptor-γt (RORγt) is necessary for Th17 cell differentiation and functions. However, the transcriptional regulation of RORγt expression, especially at the enh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Yi, Han, Chao, Wei, Zhiyuan, Dong, Hui, Shen, Xiaohe, Cui, Yiqiang, Fu, Xiaolan, Tian, Zhiqiang, Wang, Shufeng, Zhou, Jian, Yang, Di, Sun, Yi, Yuan, Jizhao, Ni, Bing, Wu, Yuzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817841/ https://www.ncbi.nlm.nih.gov/pubmed/33473108 http://dx.doi.org/10.1038/s41467-020-20786-w

Ejemplares similares

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis
por: Ruan, Qingguo, et al.
Publicado: (2011)

Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases
por: Zeng, Jiuping, et al.
Publicado: (2023)

RORγt and RORα signature genes in human Th17 cells
por: Castro, Glenda, et al.
Publicado: (2017)

Digoxin, an Overlooked Agonist of RORγ/RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation
por: Tan, Jun, et al.
Publicado: (2020)

GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease
por: Chuang, Huai-Chia, et al.
Publicado: (2018)

Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3
por: Tanaka, Shigeru, et al.
Publicado: (2014)

Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice
por: Kondo, Yuya, et al.
Publicado: (2015)

Expression of Th-17 and RORγt mRNA in Behçet’s Disease
por: Hamzaoui, Kamel, et al.
Publicado: (2011)

Sumoylation of RORγt regulates T(H)17 differentiation and thymocyte development
por: He, Zhiheng, et al.
Publicado: (2018)

Suppression of T(H)17 Differentiation and Autoimmunity by a Synthetic ROR Ligand
por: Solt, Laura A., et al.
Publicado: (2011)

The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

Transcription of RORγt in Developing Th17 Cells is Regulated by E-Proteins
por: Zhang, Fuping, et al.
Publicado: (2013)

SIRT1 deacetylates RORγt and enhances Th17 cell generation
por: Lim, Hyung W., et al.
Publicado: (2015)

SIRT1 deacetylates RORγt and enhances Th17 cell generation
por: Lim, Hyung W., et al.
Publicado: (2015)

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
por: Brucklacher-Waldert, Verena, et al.
Publicado: (2016)

RORγt(+) Treg to Th17 ratios correlate with susceptibility to Giardia infection
por: Yordanova, Ivet A., et al.
Publicado: (2019)

Decoupling the role of RORγt in the differentiation and effector function of T(H)17 cells
por: Zhong, Xiancai, et al.
Publicado: (2022)

The application of machine learning methods to the prediction of novel ligands for RORγ/RORγT receptors
por: Bachorz, Rafał A., et al.
Publicado: (2023)

Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds
por: Ding, Qingfeng, et al.
Publicado: (2015)

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo
por: Guendisch, Ulf, et al.
Publicado: (2017)

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
por: Singh, Amir Kumar, et al.
Publicado: (2018)

The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1
por: Thapa, Puspa, et al.
Publicado: (2017)

RORγt expression in mature T(H)17 cells safeguards their lineage specification by inhibiting conversion to T(H)2 cells
por: Chi, Xinxin, et al.
Publicado: (2022)

RORα and RORγ expression inversely correlates with human melanoma progression
por: Brożyna, Anna A., et al.
Publicado: (2016)

RORγ Structural Plasticity and Druggability
por: Huang, Mian, et al.
Publicado: (2020)

The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation
por: Lin, Yi-Ching, et al.
Publicado: (2016)

Pparα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes
por: Wei, Ping, et al.
Publicado: (2023)

Parthenolide Suppresses T Helper 17 and Alleviates Experimental Autoimmune Encephalomyelitis
por: Zhang, Zhihui, et al.
Publicado: (2022)

AIM2 promotes T(H)17 cells differentiation by regulating RORγt transcription activity
por: Leite, Jefferson Antônio, et al.
Publicado: (2023)

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation
por: Singh, Amir Kumar, et al.
Publicado: (2023)

Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells
por: Cornelissen, Ferry, et al.
Publicado: (2009)

Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera
por: Shi, Xiaofei, et al.
Publicado: (2019)

Methylprednisolone inhibits IFN-γ and IL-17 expression and production by cells infiltrating central nervous system in experimental autoimmune encephalomyelitis
por: Miljković, Željka, et al.
Publicado: (2009)

BAFF Promotes Th17 Cells and Aggravates Experimental Autoimmune Encephalomyelitis
por: Zhou, Xiaohui, et al.
Publicado: (2011)

In vivo equilibrium of proinflammatory IL-17(+) and regulatory IL-10(+) Foxp3(+) RORγt(+) T cells
por: Lochner, Matthias, et al.
Publicado: (2008)

Two amino acid mutation disrupts RORγt function in Th17 differentiation but not thymocyte development
por: He, Zhiheng, et al.
Publicado: (2017)

TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis
por: Mielke, Lisa A., et al.
Publicado: (2019)

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
por: Yang, Wen-Lan, et al.
Publicado: (2023)

Identification of an allosteric binding site for RORγt inhibition
por: Scheepstra, Marcel, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_el00o511hsvhv90gpboib9f9la