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The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study
PURPOSE: To assess quantitatively the choriocapillaris (CC) perfusion area in the macular area of healthy eyes, eyes with primary open-angle glaucoma, and eyes with ocular hypertension using optical coherence tomography angiography (OCTA). METHODS: A consecutive series of healthy individuals and pat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Association for Research in Vision and Ophthalmology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817881/ https://www.ncbi.nlm.nih.gov/pubmed/33475691 http://dx.doi.org/10.1167/iovs.62.1.22 |
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author | Milani, Paolo Urbini, Lara Enrica Bulone, Ennio Nava, Ugo Visintin, Deborah Cremonesi, Giorgia Scotti, Lorenza Bergamini, Fulvio |
author_facet | Milani, Paolo Urbini, Lara Enrica Bulone, Ennio Nava, Ugo Visintin, Deborah Cremonesi, Giorgia Scotti, Lorenza Bergamini, Fulvio |
author_sort | Milani, Paolo |
collection | PubMed |
description | PURPOSE: To assess quantitatively the choriocapillaris (CC) perfusion area in the macular area of healthy eyes, eyes with primary open-angle glaucoma, and eyes with ocular hypertension using optical coherence tomography angiography (OCTA). METHODS: A consecutive series of healthy individuals and patients with glaucoma and ocular hypertension were recruited prospectively in this single-center, cross-sectional study based in Milan, Italy. OCTA was performed in the morning and evening, along with a complete ophthalmologic examination. Macular superficial capillary plexus vessel density (SCP-VD) and the thicknesses of the retina and ganglion cell complex (GCC), as well as their fluctuations, were investigated. RESULTS: Thirty-nine eyes from 24 individuals with glaucoma (mean age = 58.79 ± 6 years), 43 eyes from 27 individuals with ocular hypertension (59.19 ± 6 years), and 54 eyes from 35 controls (58.27 ± 6 years) were enrolled. The mean CC perfusion area values were not significantly different among the three groups in the morning or evening (P ≥ 0.47). In contrast, SCP-VD, retinal thickness, and GCC thickness were statistically different among the groups (P ≤ 0.016), except for the foveal SCP-VD (P ≥ 0.19) and the evening foveal thickness (P = 0.57). Diurnal changes in the CC perfusion area, SCP-VD, retinal thickness, and GCC thickness were not statistically significant (P ≥ 0.16). Systemic hypertension, sex, age, axial length, and diurnal changes in intraocular pressure were not significantly associated with morning or evening measurements, or with diurnal fluctuations (P ≥ 0.07). CONCLUSIONS: The macular CC flow perfusion area appears unaffected in eyes with primary open-angle glaucoma. No significant diurnal changes were observed in any of the parameters investigated. |
format | Online Article Text |
id | pubmed-7817881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-78178812021-01-29 The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study Milani, Paolo Urbini, Lara Enrica Bulone, Ennio Nava, Ugo Visintin, Deborah Cremonesi, Giorgia Scotti, Lorenza Bergamini, Fulvio Invest Ophthalmol Vis Sci Glaucoma PURPOSE: To assess quantitatively the choriocapillaris (CC) perfusion area in the macular area of healthy eyes, eyes with primary open-angle glaucoma, and eyes with ocular hypertension using optical coherence tomography angiography (OCTA). METHODS: A consecutive series of healthy individuals and patients with glaucoma and ocular hypertension were recruited prospectively in this single-center, cross-sectional study based in Milan, Italy. OCTA was performed in the morning and evening, along with a complete ophthalmologic examination. Macular superficial capillary plexus vessel density (SCP-VD) and the thicknesses of the retina and ganglion cell complex (GCC), as well as their fluctuations, were investigated. RESULTS: Thirty-nine eyes from 24 individuals with glaucoma (mean age = 58.79 ± 6 years), 43 eyes from 27 individuals with ocular hypertension (59.19 ± 6 years), and 54 eyes from 35 controls (58.27 ± 6 years) were enrolled. The mean CC perfusion area values were not significantly different among the three groups in the morning or evening (P ≥ 0.47). In contrast, SCP-VD, retinal thickness, and GCC thickness were statistically different among the groups (P ≤ 0.016), except for the foveal SCP-VD (P ≥ 0.19) and the evening foveal thickness (P = 0.57). Diurnal changes in the CC perfusion area, SCP-VD, retinal thickness, and GCC thickness were not statistically significant (P ≥ 0.16). Systemic hypertension, sex, age, axial length, and diurnal changes in intraocular pressure were not significantly associated with morning or evening measurements, or with diurnal fluctuations (P ≥ 0.07). CONCLUSIONS: The macular CC flow perfusion area appears unaffected in eyes with primary open-angle glaucoma. No significant diurnal changes were observed in any of the parameters investigated. The Association for Research in Vision and Ophthalmology 2021-01-21 /pmc/articles/PMC7817881/ /pubmed/33475691 http://dx.doi.org/10.1167/iovs.62.1.22 Text en Copyright 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Glaucoma Milani, Paolo Urbini, Lara Enrica Bulone, Ennio Nava, Ugo Visintin, Deborah Cremonesi, Giorgia Scotti, Lorenza Bergamini, Fulvio The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study |
title | The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study |
title_full | The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study |
title_fullStr | The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study |
title_full_unstemmed | The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study |
title_short | The Macular Choriocapillaris Flow in Glaucoma and Within-Day Fluctuations: An Optical Coherence Tomography Angiography Study |
title_sort | macular choriocapillaris flow in glaucoma and within-day fluctuations: an optical coherence tomography angiography study |
topic | Glaucoma |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817881/ https://www.ncbi.nlm.nih.gov/pubmed/33475691 http://dx.doi.org/10.1167/iovs.62.1.22 |
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