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Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies

BACKGROUND/AIMS: Papillary gastric cancer (GC) is classified as differentiated adenocarcinoma, together with well-differentiated (WD) and moderately differentiated (MD) adenocarcinoma. This study evaluated the risk of lymph node metastasis (LNM) in submucosal (SM) invasive papillary GC compared with...

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Autores principales: Shin, Seung Yong, Kim, Jie-Hyun, Kook, Myeong-Cherl, Park, Do Youn, Ryu, Keun Won, Choi, Il Ju, Noh, Sung Hoon, Kim, Hyunki, Lee, Yong Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817937/
https://www.ncbi.nlm.nih.gov/pubmed/32295332
http://dx.doi.org/10.5009/gnl19328
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author Shin, Seung Yong
Kim, Jie-Hyun
Kook, Myeong-Cherl
Park, Do Youn
Ryu, Keun Won
Choi, Il Ju
Noh, Sung Hoon
Kim, Hyunki
Lee, Yong Chan
author_facet Shin, Seung Yong
Kim, Jie-Hyun
Kook, Myeong-Cherl
Park, Do Youn
Ryu, Keun Won
Choi, Il Ju
Noh, Sung Hoon
Kim, Hyunki
Lee, Yong Chan
author_sort Shin, Seung Yong
collection PubMed
description BACKGROUND/AIMS: Papillary gastric cancer (GC) is classified as differentiated adenocarcinoma, together with well-differentiated (WD) and moderately differentiated (MD) adenocarcinoma. This study evaluated the risk of lymph node metastasis (LNM) in submucosal (SM) invasive papillary GC compared with other differentiated early GC types. METHODS: This retrospective study involved three tertiary hospitals and enrolled 1,798 lesions with differentiated SM invasive GC treated with curative gastrectomy between March 2001 and December 2012. All pathology slides were reviewed, and clinicopathologic findings associated with LNM, including tumor size, location, gross type, ulceration, depth and width of SM invasion, and lymphovascular invasion (LVI), were analyzed. RESULTS: The proportion of SM papillary GC was 2.8% (n=51). SM papillary GC was associated with larger tumor size and deeper and wider SM invasion than other differentiated GC types. LNM was significantly higher in the papillary type than in the MD and WD types. LNM was found in 27.5% of SM papillary GC patients (WD 9.0%, MD 21.2%). LVI was the only significant risk factor for LNM in SM papillary GC. The depth or width of SM invasion was not associated with LNM in papillary GC. Lower third location or elevated gross appearance was significantly associated with LVI. CONCLUSIONS: SM papillary GC had the highest LNM rate, with features different from those of other differentiated SM invasive GCs. The treatment strategy for SM papillary GC should be carefully approached, especially for lesions located in the lower third or of the elevated gross type.
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spelling pubmed-78179372021-01-29 Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies Shin, Seung Yong Kim, Jie-Hyun Kook, Myeong-Cherl Park, Do Youn Ryu, Keun Won Choi, Il Ju Noh, Sung Hoon Kim, Hyunki Lee, Yong Chan Gut Liver Original Article BACKGROUND/AIMS: Papillary gastric cancer (GC) is classified as differentiated adenocarcinoma, together with well-differentiated (WD) and moderately differentiated (MD) adenocarcinoma. This study evaluated the risk of lymph node metastasis (LNM) in submucosal (SM) invasive papillary GC compared with other differentiated early GC types. METHODS: This retrospective study involved three tertiary hospitals and enrolled 1,798 lesions with differentiated SM invasive GC treated with curative gastrectomy between March 2001 and December 2012. All pathology slides were reviewed, and clinicopathologic findings associated with LNM, including tumor size, location, gross type, ulceration, depth and width of SM invasion, and lymphovascular invasion (LVI), were analyzed. RESULTS: The proportion of SM papillary GC was 2.8% (n=51). SM papillary GC was associated with larger tumor size and deeper and wider SM invasion than other differentiated GC types. LNM was significantly higher in the papillary type than in the MD and WD types. LNM was found in 27.5% of SM papillary GC patients (WD 9.0%, MD 21.2%). LVI was the only significant risk factor for LNM in SM papillary GC. The depth or width of SM invasion was not associated with LNM in papillary GC. Lower third location or elevated gross appearance was significantly associated with LVI. CONCLUSIONS: SM papillary GC had the highest LNM rate, with features different from those of other differentiated SM invasive GCs. The treatment strategy for SM papillary GC should be carefully approached, especially for lesions located in the lower third or of the elevated gross type. Editorial Office of Gut and Liver 2021-01-15 2020-04-17 /pmc/articles/PMC7817937/ /pubmed/32295332 http://dx.doi.org/10.5009/gnl19328 Text en Copyright © Gut and Liver. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shin, Seung Yong
Kim, Jie-Hyun
Kook, Myeong-Cherl
Park, Do Youn
Ryu, Keun Won
Choi, Il Ju
Noh, Sung Hoon
Kim, Hyunki
Lee, Yong Chan
Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies
title Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies
title_full Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies
title_fullStr Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies
title_full_unstemmed Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies
title_short Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies
title_sort clinicopathologic features of submucosal papillary gastric cancer differ from those of other differentiated-type histologies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817937/
https://www.ncbi.nlm.nih.gov/pubmed/32295332
http://dx.doi.org/10.5009/gnl19328
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