Quantitative Differentiation of Protein Aggregates From Other Subvisible Particles in Viscous Mixtures Through Holographic Characterization

We demonstrate the use of holographic video microscopy to detect individual subvisible particles dispersed in biopharmaceutical formulations and to differentiate them based on material characteristics measured from their holograms. The result of holographic analysis is a precise and accurate measure...

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Detalles Bibliográficos
Autores principales: Winters, Annemarie, Cheong, Fook Chiong, Odete, Mary Ann, Lumer, Juliana, Ruffner, David B., Mishra, Kimberly I., Grier, David G., Philips, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818018/
https://www.ncbi.nlm.nih.gov/pubmed/32439328
http://dx.doi.org/10.1016/j.xphs.2020.05.002

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