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Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

BACKGROUND: As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk...

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Autores principales: Wu, Zhiqiang, Han, Yelin, Liu, Bo, Li, Hongying, Zhu, Guangjian, Latinne, Alice, Dong, Jie, Sun, Lilin, Su, Haoxiang, Liu, Liguo, Du, Jiang, Zhou, Siyu, Chen, Mingxing, Kritiyakan, Anamika, Jittapalapong, Sathaporn, Chaisiri, Kittipong, Buchy, Phillipe, Duong, Veasna, Yang, Jian, Jiang, Jinyong, Xu, Xiang, Zhou, Hongning, Yang, Fan, Irwin, David M., Morand, Serge, Daszak, Peter, Wang, Jianwei, Jin, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818139/
https://www.ncbi.nlm.nih.gov/pubmed/33478588
http://dx.doi.org/10.1186/s40168-020-00965-z
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author Wu, Zhiqiang
Han, Yelin
Liu, Bo
Li, Hongying
Zhu, Guangjian
Latinne, Alice
Dong, Jie
Sun, Lilin
Su, Haoxiang
Liu, Liguo
Du, Jiang
Zhou, Siyu
Chen, Mingxing
Kritiyakan, Anamika
Jittapalapong, Sathaporn
Chaisiri, Kittipong
Buchy, Phillipe
Duong, Veasna
Yang, Jian
Jiang, Jinyong
Xu, Xiang
Zhou, Hongning
Yang, Fan
Irwin, David M.
Morand, Serge
Daszak, Peter
Wang, Jianwei
Jin, Qi
author_facet Wu, Zhiqiang
Han, Yelin
Liu, Bo
Li, Hongying
Zhu, Guangjian
Latinne, Alice
Dong, Jie
Sun, Lilin
Su, Haoxiang
Liu, Liguo
Du, Jiang
Zhou, Siyu
Chen, Mingxing
Kritiyakan, Anamika
Jittapalapong, Sathaporn
Chaisiri, Kittipong
Buchy, Phillipe
Duong, Veasna
Yang, Jian
Jiang, Jinyong
Xu, Xiang
Zhou, Hongning
Yang, Fan
Irwin, David M.
Morand, Serge
Daszak, Peter
Wang, Jianwei
Jin, Qi
author_sort Wu, Zhiqiang
collection PubMed
description BACKGROUND: As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens. RESULTS: This study aimed to describe the viral range that could be detected in the lungs of rodents from Mainland Southeast Asia. Lung samples were collected from 3284 rodents and insectivores of the orders Rodentia, Scandentia, and Eulipotyphla in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006–2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of the mammalian viruses within these lungs and the ecological and genetic imprints of the novel viruses. Many mammalian- or arthropod-related viruses from distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genomic and evolutionary characteristics, host species, and locations. CONCLUSIONS: These results expand our understanding of the core viromes of rodents and insectivores from Mainland Southeast Asia and suggest that a high diversity of viruses remains to be found in rodent species of this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40168-020-00965-z.
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spelling pubmed-78181392021-01-21 Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia Wu, Zhiqiang Han, Yelin Liu, Bo Li, Hongying Zhu, Guangjian Latinne, Alice Dong, Jie Sun, Lilin Su, Haoxiang Liu, Liguo Du, Jiang Zhou, Siyu Chen, Mingxing Kritiyakan, Anamika Jittapalapong, Sathaporn Chaisiri, Kittipong Buchy, Phillipe Duong, Veasna Yang, Jian Jiang, Jinyong Xu, Xiang Zhou, Hongning Yang, Fan Irwin, David M. Morand, Serge Daszak, Peter Wang, Jianwei Jin, Qi Microbiome Research BACKGROUND: As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens. RESULTS: This study aimed to describe the viral range that could be detected in the lungs of rodents from Mainland Southeast Asia. Lung samples were collected from 3284 rodents and insectivores of the orders Rodentia, Scandentia, and Eulipotyphla in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006–2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of the mammalian viruses within these lungs and the ecological and genetic imprints of the novel viruses. Many mammalian- or arthropod-related viruses from distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genomic and evolutionary characteristics, host species, and locations. CONCLUSIONS: These results expand our understanding of the core viromes of rodents and insectivores from Mainland Southeast Asia and suggest that a high diversity of viruses remains to be found in rodent species of this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40168-020-00965-z. BioMed Central 2021-01-21 /pmc/articles/PMC7818139/ /pubmed/33478588 http://dx.doi.org/10.1186/s40168-020-00965-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wu, Zhiqiang
Han, Yelin
Liu, Bo
Li, Hongying
Zhu, Guangjian
Latinne, Alice
Dong, Jie
Sun, Lilin
Su, Haoxiang
Liu, Liguo
Du, Jiang
Zhou, Siyu
Chen, Mingxing
Kritiyakan, Anamika
Jittapalapong, Sathaporn
Chaisiri, Kittipong
Buchy, Phillipe
Duong, Veasna
Yang, Jian
Jiang, Jinyong
Xu, Xiang
Zhou, Hongning
Yang, Fan
Irwin, David M.
Morand, Serge
Daszak, Peter
Wang, Jianwei
Jin, Qi
Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia
title Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia
title_full Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia
title_fullStr Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia
title_full_unstemmed Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia
title_short Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia
title_sort decoding the rna viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in mainland southeast asia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818139/
https://www.ncbi.nlm.nih.gov/pubmed/33478588
http://dx.doi.org/10.1186/s40168-020-00965-z
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