Cargando…
Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural s...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818196/ https://www.ncbi.nlm.nih.gov/pubmed/33081517 http://dx.doi.org/10.1177/1535759720964775 |
_version_ | 1783638783571263488 |
---|---|
author | Lam, Alice D. Noebels, Jeffrey |
author_facet | Lam, Alice D. Noebels, Jeffrey |
author_sort | Lam, Alice D. |
collection | PubMed |
description | Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral seizures in mouse AD models, build the case for epileptogenesis as an early therapeutic target for AD. Since most individuals with AD do not develop overt seizures, leveraging functional biomarkers of epilepsy risk to stratify a heterogeneous AD patient population for treatment is research priority for successful clinical trial design. Who will benefit from antiseizure interventions, which one, and when should it begin? |
format | Online Article Text |
id | pubmed-7818196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78181962021-01-28 Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease Lam, Alice D. Noebels, Jeffrey Epilepsy Curr Current Review in Basic Science Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral seizures in mouse AD models, build the case for epileptogenesis as an early therapeutic target for AD. Since most individuals with AD do not develop overt seizures, leveraging functional biomarkers of epilepsy risk to stratify a heterogeneous AD patient population for treatment is research priority for successful clinical trial design. Who will benefit from antiseizure interventions, which one, and when should it begin? SAGE Publications 2020-10-20 /pmc/articles/PMC7818196/ /pubmed/33081517 http://dx.doi.org/10.1177/1535759720964775 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Current Review in Basic Science Lam, Alice D. Noebels, Jeffrey Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease |
title | Night Watch on the Titanic: Detecting Early Signs of
Epileptogenesis in Alzheimer Disease |
title_full | Night Watch on the Titanic: Detecting Early Signs of
Epileptogenesis in Alzheimer Disease |
title_fullStr | Night Watch on the Titanic: Detecting Early Signs of
Epileptogenesis in Alzheimer Disease |
title_full_unstemmed | Night Watch on the Titanic: Detecting Early Signs of
Epileptogenesis in Alzheimer Disease |
title_short | Night Watch on the Titanic: Detecting Early Signs of
Epileptogenesis in Alzheimer Disease |
title_sort | night watch on the titanic: detecting early signs of
epileptogenesis in alzheimer disease |
topic | Current Review in Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818196/ https://www.ncbi.nlm.nih.gov/pubmed/33081517 http://dx.doi.org/10.1177/1535759720964775 |
work_keys_str_mv | AT lamaliced nightwatchonthetitanicdetectingearlysignsofepileptogenesisinalzheimerdisease AT noebelsjeffrey nightwatchonthetitanicdetectingearlysignsofepileptogenesisinalzheimerdisease |