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Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease

Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural s...

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Detalles Bibliográficos
Autores principales: Lam, Alice D., Noebels, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818196/
https://www.ncbi.nlm.nih.gov/pubmed/33081517
http://dx.doi.org/10.1177/1535759720964775
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author Lam, Alice D.
Noebels, Jeffrey
author_facet Lam, Alice D.
Noebels, Jeffrey
author_sort Lam, Alice D.
collection PubMed
description Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral seizures in mouse AD models, build the case for epileptogenesis as an early therapeutic target for AD. Since most individuals with AD do not develop overt seizures, leveraging functional biomarkers of epilepsy risk to stratify a heterogeneous AD patient population for treatment is research priority for successful clinical trial design. Who will benefit from antiseizure interventions, which one, and when should it begin?
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spelling pubmed-78181962021-01-28 Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease Lam, Alice D. Noebels, Jeffrey Epilepsy Curr Current Review in Basic Science Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral seizures in mouse AD models, build the case for epileptogenesis as an early therapeutic target for AD. Since most individuals with AD do not develop overt seizures, leveraging functional biomarkers of epilepsy risk to stratify a heterogeneous AD patient population for treatment is research priority for successful clinical trial design. Who will benefit from antiseizure interventions, which one, and when should it begin? SAGE Publications 2020-10-20 /pmc/articles/PMC7818196/ /pubmed/33081517 http://dx.doi.org/10.1177/1535759720964775 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Current Review in Basic Science
Lam, Alice D.
Noebels, Jeffrey
Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
title Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
title_full Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
title_fullStr Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
title_full_unstemmed Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
title_short Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease
title_sort night watch on the titanic: detecting early signs of epileptogenesis in alzheimer disease
topic Current Review in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818196/
https://www.ncbi.nlm.nih.gov/pubmed/33081517
http://dx.doi.org/10.1177/1535759720964775
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