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Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications
Proteins have attracted increasing attention as biopharmaceutics and diagnostics due to their high specificity, biocompatibility, and biodegradability. The biopharmaceutical sector in particular is experiencing rapid growth, which has led to an increase in the production and sale of protein drugs an...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818443/ https://www.ncbi.nlm.nih.gov/pubmed/32667697 http://dx.doi.org/10.1002/cmdc.202000412 |
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author | Kuan, Seah Ling Raabe, Marco |
author_facet | Kuan, Seah Ling Raabe, Marco |
author_sort | Kuan, Seah Ling |
collection | PubMed |
description | Proteins have attracted increasing attention as biopharmaceutics and diagnostics due to their high specificity, biocompatibility, and biodegradability. The biopharmaceutical sector in particular is experiencing rapid growth, which has led to an increase in the production and sale of protein drugs and diagnostics over the last two decades. Since the first‐generation biopharmaceutics dominated by native proteins, both recombinant and chemical technologies have evolved and transformed the outlook of this rapidly developing field. This review article presents updates on the fabrication of covalent and supramolecular fusion hybrids, as well as protein‐polymer hybrids using solid‐phase approaches that hold great promise for preparing protein hybrids with precise control at the macromolecular level to incorporate additional features. In addition, the applications of the resultant protein hybrids in medicine and diagnostics are highlighted where possible. |
format | Online Article Text |
id | pubmed-7818443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78184432021-01-29 Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications Kuan, Seah Ling Raabe, Marco ChemMedChem Minireviews Proteins have attracted increasing attention as biopharmaceutics and diagnostics due to their high specificity, biocompatibility, and biodegradability. The biopharmaceutical sector in particular is experiencing rapid growth, which has led to an increase in the production and sale of protein drugs and diagnostics over the last two decades. Since the first‐generation biopharmaceutics dominated by native proteins, both recombinant and chemical technologies have evolved and transformed the outlook of this rapidly developing field. This review article presents updates on the fabrication of covalent and supramolecular fusion hybrids, as well as protein‐polymer hybrids using solid‐phase approaches that hold great promise for preparing protein hybrids with precise control at the macromolecular level to incorporate additional features. In addition, the applications of the resultant protein hybrids in medicine and diagnostics are highlighted where possible. John Wiley and Sons Inc. 2020-08-13 2021-01-08 /pmc/articles/PMC7818443/ /pubmed/32667697 http://dx.doi.org/10.1002/cmdc.202000412 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Minireviews Kuan, Seah Ling Raabe, Marco Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications |
title | Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications |
title_full | Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications |
title_fullStr | Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications |
title_full_unstemmed | Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications |
title_short | Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications |
title_sort | solid‐phase protein modifications: towards precision protein hybrids for biological applications |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818443/ https://www.ncbi.nlm.nih.gov/pubmed/32667697 http://dx.doi.org/10.1002/cmdc.202000412 |
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