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Risk factors for cerebral palsy in neonates due to placental abruption
AIM: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. METHODS: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant w...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818445/ https://www.ncbi.nlm.nih.gov/pubmed/32885550 http://dx.doi.org/10.1111/jog.14447 |
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author | Ichizuka, Kiyotake Toyokawa, Satoshi Ikenoue, Tsuyomu Satoh, Shoji Hasegawa, Junichi Ikeda, Tomoaki Tamiya, Nanako Nakai, Akihito Fujimori, Keiya Maeda, Tsugio Kanayama, Naohiro Masuzaki, Hideaki Iwashita, Mitsutoshi Suzuki, Hideaki Takeda, Satoru |
author_facet | Ichizuka, Kiyotake Toyokawa, Satoshi Ikenoue, Tsuyomu Satoh, Shoji Hasegawa, Junichi Ikeda, Tomoaki Tamiya, Nanako Nakai, Akihito Fujimori, Keiya Maeda, Tsugio Kanayama, Naohiro Masuzaki, Hideaki Iwashita, Mitsutoshi Suzuki, Hideaki Takeda, Satoru |
author_sort | Ichizuka, Kiyotake |
collection | PubMed |
description | AIM: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. METHODS: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant women (n = 122) who delivered an infant with CP between 2009 and 2015, where placental abruption was identified as the single cause of CP. The control group consisted of pregnant women with placental abruption, who delivered an infant without CP and were managed from 2013 to 2014. They were randomly identified from the prenatal database of the Japan Society of Obstetrics and Gynecology (JSOG‐DB; n = 1214). Risk factors were investigated using multivariate analysis. RESULTS: Alcohol consumption (3.38, 2.01–5.68) (odds ratio, 95% confidence interval), smoking during pregnancy (3.50, 1.32–9.25), number of deliveries (1.28, 1.05–1.56), polyhydramnios (5.60, 1.37–22.6), oral administration of ritodrine hydrochloride (2.09, 1.22–3.57) and hypertensive disorders in pregnancy (2.25, 1.27–4.07) were significant risk factors. In contrast, intravenous administration of oxytocin (odds ratio, 95% confidence interval: 0.22, 0.09–0.58) and magnesium sulfate (0.122, 0.02–0.89) attenuated risk. CONCLUSION: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption. Regarding alcohol consumption and smoking during pregnancy, the results suggest the importance of educational activities targeting pregnant women to increase their awareness of placental abruption. |
format | Online Article Text |
id | pubmed-7818445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78184452021-01-29 Risk factors for cerebral palsy in neonates due to placental abruption Ichizuka, Kiyotake Toyokawa, Satoshi Ikenoue, Tsuyomu Satoh, Shoji Hasegawa, Junichi Ikeda, Tomoaki Tamiya, Nanako Nakai, Akihito Fujimori, Keiya Maeda, Tsugio Kanayama, Naohiro Masuzaki, Hideaki Iwashita, Mitsutoshi Suzuki, Hideaki Takeda, Satoru J Obstet Gynaecol Res Original Articles AIM: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. METHODS: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant women (n = 122) who delivered an infant with CP between 2009 and 2015, where placental abruption was identified as the single cause of CP. The control group consisted of pregnant women with placental abruption, who delivered an infant without CP and were managed from 2013 to 2014. They were randomly identified from the prenatal database of the Japan Society of Obstetrics and Gynecology (JSOG‐DB; n = 1214). Risk factors were investigated using multivariate analysis. RESULTS: Alcohol consumption (3.38, 2.01–5.68) (odds ratio, 95% confidence interval), smoking during pregnancy (3.50, 1.32–9.25), number of deliveries (1.28, 1.05–1.56), polyhydramnios (5.60, 1.37–22.6), oral administration of ritodrine hydrochloride (2.09, 1.22–3.57) and hypertensive disorders in pregnancy (2.25, 1.27–4.07) were significant risk factors. In contrast, intravenous administration of oxytocin (odds ratio, 95% confidence interval: 0.22, 0.09–0.58) and magnesium sulfate (0.122, 0.02–0.89) attenuated risk. CONCLUSION: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption. Regarding alcohol consumption and smoking during pregnancy, the results suggest the importance of educational activities targeting pregnant women to increase their awareness of placental abruption. John Wiley & Sons Australia, Ltd 2020-09-03 2021-01 /pmc/articles/PMC7818445/ /pubmed/32885550 http://dx.doi.org/10.1111/jog.14447 Text en © 2020 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Ichizuka, Kiyotake Toyokawa, Satoshi Ikenoue, Tsuyomu Satoh, Shoji Hasegawa, Junichi Ikeda, Tomoaki Tamiya, Nanako Nakai, Akihito Fujimori, Keiya Maeda, Tsugio Kanayama, Naohiro Masuzaki, Hideaki Iwashita, Mitsutoshi Suzuki, Hideaki Takeda, Satoru Risk factors for cerebral palsy in neonates due to placental abruption |
title | Risk factors for cerebral palsy in neonates due to placental abruption |
title_full | Risk factors for cerebral palsy in neonates due to placental abruption |
title_fullStr | Risk factors for cerebral palsy in neonates due to placental abruption |
title_full_unstemmed | Risk factors for cerebral palsy in neonates due to placental abruption |
title_short | Risk factors for cerebral palsy in neonates due to placental abruption |
title_sort | risk factors for cerebral palsy in neonates due to placental abruption |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818445/ https://www.ncbi.nlm.nih.gov/pubmed/32885550 http://dx.doi.org/10.1111/jog.14447 |
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