Cargando…

Risk factors for cerebral palsy in neonates due to placental abruption

AIM: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. METHODS: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant w...

Descripción completa

Detalles Bibliográficos
Autores principales: Ichizuka, Kiyotake, Toyokawa, Satoshi, Ikenoue, Tsuyomu, Satoh, Shoji, Hasegawa, Junichi, Ikeda, Tomoaki, Tamiya, Nanako, Nakai, Akihito, Fujimori, Keiya, Maeda, Tsugio, Kanayama, Naohiro, Masuzaki, Hideaki, Iwashita, Mitsutoshi, Suzuki, Hideaki, Takeda, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818445/
https://www.ncbi.nlm.nih.gov/pubmed/32885550
http://dx.doi.org/10.1111/jog.14447
_version_ 1783638836838924288
author Ichizuka, Kiyotake
Toyokawa, Satoshi
Ikenoue, Tsuyomu
Satoh, Shoji
Hasegawa, Junichi
Ikeda, Tomoaki
Tamiya, Nanako
Nakai, Akihito
Fujimori, Keiya
Maeda, Tsugio
Kanayama, Naohiro
Masuzaki, Hideaki
Iwashita, Mitsutoshi
Suzuki, Hideaki
Takeda, Satoru
author_facet Ichizuka, Kiyotake
Toyokawa, Satoshi
Ikenoue, Tsuyomu
Satoh, Shoji
Hasegawa, Junichi
Ikeda, Tomoaki
Tamiya, Nanako
Nakai, Akihito
Fujimori, Keiya
Maeda, Tsugio
Kanayama, Naohiro
Masuzaki, Hideaki
Iwashita, Mitsutoshi
Suzuki, Hideaki
Takeda, Satoru
author_sort Ichizuka, Kiyotake
collection PubMed
description AIM: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. METHODS: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant women (n = 122) who delivered an infant with CP between 2009 and 2015, where placental abruption was identified as the single cause of CP. The control group consisted of pregnant women with placental abruption, who delivered an infant without CP and were managed from 2013 to 2014. They were randomly identified from the prenatal database of the Japan Society of Obstetrics and Gynecology (JSOG‐DB; n = 1214). Risk factors were investigated using multivariate analysis. RESULTS: Alcohol consumption (3.38, 2.01–5.68) (odds ratio, 95% confidence interval), smoking during pregnancy (3.50, 1.32–9.25), number of deliveries (1.28, 1.05–1.56), polyhydramnios (5.60, 1.37–22.6), oral administration of ritodrine hydrochloride (2.09, 1.22–3.57) and hypertensive disorders in pregnancy (2.25, 1.27–4.07) were significant risk factors. In contrast, intravenous administration of oxytocin (odds ratio, 95% confidence interval: 0.22, 0.09–0.58) and magnesium sulfate (0.122, 0.02–0.89) attenuated risk. CONCLUSION: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption. Regarding alcohol consumption and smoking during pregnancy, the results suggest the importance of educational activities targeting pregnant women to increase their awareness of placental abruption.
format Online
Article
Text
id pubmed-7818445
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley & Sons Australia, Ltd
record_format MEDLINE/PubMed
spelling pubmed-78184452021-01-29 Risk factors for cerebral palsy in neonates due to placental abruption Ichizuka, Kiyotake Toyokawa, Satoshi Ikenoue, Tsuyomu Satoh, Shoji Hasegawa, Junichi Ikeda, Tomoaki Tamiya, Nanako Nakai, Akihito Fujimori, Keiya Maeda, Tsugio Kanayama, Naohiro Masuzaki, Hideaki Iwashita, Mitsutoshi Suzuki, Hideaki Takeda, Satoru J Obstet Gynaecol Res Original Articles AIM: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. METHODS: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant women (n = 122) who delivered an infant with CP between 2009 and 2015, where placental abruption was identified as the single cause of CP. The control group consisted of pregnant women with placental abruption, who delivered an infant without CP and were managed from 2013 to 2014. They were randomly identified from the prenatal database of the Japan Society of Obstetrics and Gynecology (JSOG‐DB; n = 1214). Risk factors were investigated using multivariate analysis. RESULTS: Alcohol consumption (3.38, 2.01–5.68) (odds ratio, 95% confidence interval), smoking during pregnancy (3.50, 1.32–9.25), number of deliveries (1.28, 1.05–1.56), polyhydramnios (5.60, 1.37–22.6), oral administration of ritodrine hydrochloride (2.09, 1.22–3.57) and hypertensive disorders in pregnancy (2.25, 1.27–4.07) were significant risk factors. In contrast, intravenous administration of oxytocin (odds ratio, 95% confidence interval: 0.22, 0.09–0.58) and magnesium sulfate (0.122, 0.02–0.89) attenuated risk. CONCLUSION: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption. Regarding alcohol consumption and smoking during pregnancy, the results suggest the importance of educational activities targeting pregnant women to increase their awareness of placental abruption. John Wiley & Sons Australia, Ltd 2020-09-03 2021-01 /pmc/articles/PMC7818445/ /pubmed/32885550 http://dx.doi.org/10.1111/jog.14447 Text en © 2020 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ichizuka, Kiyotake
Toyokawa, Satoshi
Ikenoue, Tsuyomu
Satoh, Shoji
Hasegawa, Junichi
Ikeda, Tomoaki
Tamiya, Nanako
Nakai, Akihito
Fujimori, Keiya
Maeda, Tsugio
Kanayama, Naohiro
Masuzaki, Hideaki
Iwashita, Mitsutoshi
Suzuki, Hideaki
Takeda, Satoru
Risk factors for cerebral palsy in neonates due to placental abruption
title Risk factors for cerebral palsy in neonates due to placental abruption
title_full Risk factors for cerebral palsy in neonates due to placental abruption
title_fullStr Risk factors for cerebral palsy in neonates due to placental abruption
title_full_unstemmed Risk factors for cerebral palsy in neonates due to placental abruption
title_short Risk factors for cerebral palsy in neonates due to placental abruption
title_sort risk factors for cerebral palsy in neonates due to placental abruption
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818445/
https://www.ncbi.nlm.nih.gov/pubmed/32885550
http://dx.doi.org/10.1111/jog.14447
work_keys_str_mv AT ichizukakiyotake riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT toyokawasatoshi riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT ikenouetsuyomu riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT satohshoji riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT hasegawajunichi riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT ikedatomoaki riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT tamiyananako riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT nakaiakihito riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT fujimorikeiya riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT maedatsugio riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT kanayamanaohiro riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT masuzakihideaki riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT iwashitamitsutoshi riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT suzukihideaki riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption
AT takedasatoru riskfactorsforcerebralpalsyinneonatesduetoplacentalabruption