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The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes

Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from multiple NMAs becomes a nontrivial task, especially for larger networks. Moreo...

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Autores principales: Seo, Michael, Furukawa, Toshi A., Veroniki, Areti Angeliki, Pillinger, Toby, Tomlinson, Anneka, Salanti, Georgia, Cipriani, Andrea, Efthimiou, Orestis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818463/
https://www.ncbi.nlm.nih.gov/pubmed/32524754
http://dx.doi.org/10.1002/jrsm.1428
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author Seo, Michael
Furukawa, Toshi A.
Veroniki, Areti Angeliki
Pillinger, Toby
Tomlinson, Anneka
Salanti, Georgia
Cipriani, Andrea
Efthimiou, Orestis
author_facet Seo, Michael
Furukawa, Toshi A.
Veroniki, Areti Angeliki
Pillinger, Toby
Tomlinson, Anneka
Salanti, Georgia
Cipriani, Andrea
Efthimiou, Orestis
author_sort Seo, Michael
collection PubMed
description Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from multiple NMAs becomes a nontrivial task, especially for larger networks. Moreover, NMAs provide results in terms of relative effect measures that can be difficult to interpret and apply in every‐day clinical practice, such as the odds ratios. In this article, we aim to facilitate the clinical decision‐making process by proposing a new graphical tool, the Kilim plot, for presenting results from NMA on multiple outcomes. Our plot compactly summarizes results on all treatments and all outcomes; it provides information regarding the strength of the statistical evidence of treatment effects, while it illustrates absolute, rather than relative, effects of interventions. Moreover, it can be easily modified to include considerations regarding clinically important effects. To showcase our method, we use data from a network of studies in antidepressants. All analyses are performed in R and we provide the source code needed to produce the Kilim plot, as well as an interactive web application.
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spelling pubmed-78184632021-01-29 The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes Seo, Michael Furukawa, Toshi A. Veroniki, Areti Angeliki Pillinger, Toby Tomlinson, Anneka Salanti, Georgia Cipriani, Andrea Efthimiou, Orestis Res Synth Methods Special Issue Papers Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from multiple NMAs becomes a nontrivial task, especially for larger networks. Moreover, NMAs provide results in terms of relative effect measures that can be difficult to interpret and apply in every‐day clinical practice, such as the odds ratios. In this article, we aim to facilitate the clinical decision‐making process by proposing a new graphical tool, the Kilim plot, for presenting results from NMA on multiple outcomes. Our plot compactly summarizes results on all treatments and all outcomes; it provides information regarding the strength of the statistical evidence of treatment effects, while it illustrates absolute, rather than relative, effects of interventions. Moreover, it can be easily modified to include considerations regarding clinically important effects. To showcase our method, we use data from a network of studies in antidepressants. All analyses are performed in R and we provide the source code needed to produce the Kilim plot, as well as an interactive web application. John Wiley and Sons Inc. 2020-07-16 2021-01 /pmc/articles/PMC7818463/ /pubmed/32524754 http://dx.doi.org/10.1002/jrsm.1428 Text en © 2020 The Authors. Research Synthesis Methods published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Papers
Seo, Michael
Furukawa, Toshi A.
Veroniki, Areti Angeliki
Pillinger, Toby
Tomlinson, Anneka
Salanti, Georgia
Cipriani, Andrea
Efthimiou, Orestis
The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
title The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
title_full The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
title_fullStr The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
title_full_unstemmed The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
title_short The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
title_sort kilim plot: a tool for visualizing network meta‐analysis results for multiple outcomes
topic Special Issue Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818463/
https://www.ncbi.nlm.nih.gov/pubmed/32524754
http://dx.doi.org/10.1002/jrsm.1428
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