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3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth

The microstructure of porous scaffolds plays a vital role in bone regeneration, but its optimal shape is still unclear. In this study, four kinds of porous titanium alloy scaffolds with similar porosities (65%) and pore sizes (650 μm) and different structures were prepared by selective laser melting...

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Autores principales: Deng, Fuyuan, Liu, Linlin, Li, Zhong, Liu, Juncai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818551/
https://www.ncbi.nlm.nih.gov/pubmed/33478505
http://dx.doi.org/10.1186/s13036-021-00255-8
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author Deng, Fuyuan
Liu, Linlin
Li, Zhong
Liu, Juncai
author_facet Deng, Fuyuan
Liu, Linlin
Li, Zhong
Liu, Juncai
author_sort Deng, Fuyuan
collection PubMed
description The microstructure of porous scaffolds plays a vital role in bone regeneration, but its optimal shape is still unclear. In this study, four kinds of porous titanium alloy scaffolds with similar porosities (65%) and pore sizes (650 μm) and different structures were prepared by selective laser melting. Four scaffolds were implanted into the distal femur of rabbits to evaluate bone tissue growth in vivo. Micro-CT and hard tissue section analyses were performed 6 and 12 weeks after the operation to reveal the bone growth of the porous scaffold. The results show that diamond lattice unit (DIA) bone growth is the best of the four topological scaffolds. Through computational fluid dynamics (CFD) analysis, the permeability, velocity and flow trajectory inside the scaffold structure were calculated. The internal fluid velocity difference of the DIA structure is the smallest, and the trajectory of fluid flow inside the scaffold is the longest, which is beneficial for blood vessel growth, nutrient transport and bone formation. In this study, the mechanism of bone growth in different structures was revealed by in vivo experiments combined with CFD, providing a new theoretical basis for the design of bone scaffolds in the future.
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spelling pubmed-78185512021-01-22 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth Deng, Fuyuan Liu, Linlin Li, Zhong Liu, Juncai J Biol Eng Research The microstructure of porous scaffolds plays a vital role in bone regeneration, but its optimal shape is still unclear. In this study, four kinds of porous titanium alloy scaffolds with similar porosities (65%) and pore sizes (650 μm) and different structures were prepared by selective laser melting. Four scaffolds were implanted into the distal femur of rabbits to evaluate bone tissue growth in vivo. Micro-CT and hard tissue section analyses were performed 6 and 12 weeks after the operation to reveal the bone growth of the porous scaffold. The results show that diamond lattice unit (DIA) bone growth is the best of the four topological scaffolds. Through computational fluid dynamics (CFD) analysis, the permeability, velocity and flow trajectory inside the scaffold structure were calculated. The internal fluid velocity difference of the DIA structure is the smallest, and the trajectory of fluid flow inside the scaffold is the longest, which is beneficial for blood vessel growth, nutrient transport and bone formation. In this study, the mechanism of bone growth in different structures was revealed by in vivo experiments combined with CFD, providing a new theoretical basis for the design of bone scaffolds in the future. BioMed Central 2021-01-21 /pmc/articles/PMC7818551/ /pubmed/33478505 http://dx.doi.org/10.1186/s13036-021-00255-8 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Deng, Fuyuan
Liu, Linlin
Li, Zhong
Liu, Juncai
3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth
title 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth
title_full 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth
title_fullStr 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth
title_full_unstemmed 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth
title_short 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth
title_sort 3d printed ti6al4v bone scaffolds with different pore structure effects on bone ingrowth
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818551/
https://www.ncbi.nlm.nih.gov/pubmed/33478505
http://dx.doi.org/10.1186/s13036-021-00255-8
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