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Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes

BACKGROUND: The Environmental Determinants of Diabetes in the Young (TEDDY) is a prospective birth cohort designed to study type 1 diabetes (T1D) by following children with high genetic risk. An integrative multi-omics approach was used to evaluate islet autoimmunity etiology, identify disease bioma...

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Detalles Bibliográficos
Autores principales:	Balzano-Nogueira, Leandro, Ramirez, Ricardo, Zamkovaya, Tatyana, Dailey, Jordan, Ardissone, Alexandria N., Chamala, Srikar, Serrano-Quílez, Joan, Rubio, Teresa, Haller, Michael J., Concannon, Patrick, Atkinson, Mark A., Schatz, Desmond A., Triplett, Eric W., Conesa, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818777/ https://www.ncbi.nlm.nih.gov/pubmed/33478573 http://dx.doi.org/10.1186/s13059-021-02262-w

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