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Progenies of NG2 glia: what do we learn from transgenic mouse models ?

In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There...

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Detalles Bibliográficos
Autores principales: Guo, Qilin, Scheller, Anja, Huang, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818854/
https://www.ncbi.nlm.nih.gov/pubmed/32788446
http://dx.doi.org/10.4103/1673-5374.286950
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author Guo, Qilin
Scheller, Anja
Huang, Wenhui
author_facet Guo, Qilin
Scheller, Anja
Huang, Wenhui
author_sort Guo, Qilin
collection PubMed
description In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain, whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence. This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development. We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential. We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies.
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spelling pubmed-78188542021-01-22 Progenies of NG2 glia: what do we learn from transgenic mouse models ? Guo, Qilin Scheller, Anja Huang, Wenhui Neural Regen Res Review In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain, whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence. This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development. We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential. We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies. Wolters Kluwer - Medknow 2020-08-10 /pmc/articles/PMC7818854/ /pubmed/32788446 http://dx.doi.org/10.4103/1673-5374.286950 Text en Copyright: © 2021 Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Guo, Qilin
Scheller, Anja
Huang, Wenhui
Progenies of NG2 glia: what do we learn from transgenic mouse models ?
title Progenies of NG2 glia: what do we learn from transgenic mouse models ?
title_full Progenies of NG2 glia: what do we learn from transgenic mouse models ?
title_fullStr Progenies of NG2 glia: what do we learn from transgenic mouse models ?
title_full_unstemmed Progenies of NG2 glia: what do we learn from transgenic mouse models ?
title_short Progenies of NG2 glia: what do we learn from transgenic mouse models ?
title_sort progenies of ng2 glia: what do we learn from transgenic mouse models ?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818854/
https://www.ncbi.nlm.nih.gov/pubmed/32788446
http://dx.doi.org/10.4103/1673-5374.286950
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