Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague–Dawley Rats

[Image: see text] Organophosphorus esters (OPs) were originally developed as pesticides but were repurposed as easily manufactured, inexpensive, and highly toxic chemical warfare agents. Acute OP toxicity is primarily due to inhibition of acetylcholinesterase (AChE), an enzyme in the central and per...

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Autores principales: Hayes, Thomas R., Chao, Chih-Kai, Blecha, Joseph E., Huynh, Tony L., Zinn, Kurt R., Thompson, Charles M., Gerdes, John M., VanBrocklin, Henry F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818893/
https://www.ncbi.nlm.nih.gov/pubmed/33373198
http://dx.doi.org/10.1021/acs.chemrestox.0c00237

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