Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration

Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic differentiation. Osteogenic differentiation includes matrix secretion and calcium minerali...

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Autores principales: Zhou, Zimo, Hossain, Mohammad Showkat, Liu, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819155/
https://www.ncbi.nlm.nih.gov/pubmed/33478579
http://dx.doi.org/10.1186/s13287-021-02149-4
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author Zhou, Zimo
Hossain, Mohammad Showkat
Liu, Da
author_facet Zhou, Zimo
Hossain, Mohammad Showkat
Liu, Da
author_sort Zhou, Zimo
collection PubMed
description Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic differentiation. Osteogenic differentiation includes matrix secretion and calcium mineralization as hallmarks of osteoblast differentiation and the absorption of calcium and phosphorus as hallmarks of osteoclast differentiation. Mesenchymal stem cells (MSCs) form osteoprogenitor cells, pre-osteoblasts, mature osteoblasts, and osteocytes through induction and differentiation. lncRNAs regulate the expression of coding genes and play essential roles in osteogenic differentiation and bone regeneration. The lncRNA H19 is known to have vital roles in osteogenic induction. This review highlights the role of H19 as a novel target for osteogenic differentiation and the promotion of bone regeneration.
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spelling pubmed-78191552021-01-22 Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration Zhou, Zimo Hossain, Mohammad Showkat Liu, Da Stem Cell Res Ther Review Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic differentiation. Osteogenic differentiation includes matrix secretion and calcium mineralization as hallmarks of osteoblast differentiation and the absorption of calcium and phosphorus as hallmarks of osteoclast differentiation. Mesenchymal stem cells (MSCs) form osteoprogenitor cells, pre-osteoblasts, mature osteoblasts, and osteocytes through induction and differentiation. lncRNAs regulate the expression of coding genes and play essential roles in osteogenic differentiation and bone regeneration. The lncRNA H19 is known to have vital roles in osteogenic induction. This review highlights the role of H19 as a novel target for osteogenic differentiation and the promotion of bone regeneration. BioMed Central 2021-01-21 /pmc/articles/PMC7819155/ /pubmed/33478579 http://dx.doi.org/10.1186/s13287-021-02149-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhou, Zimo
Hossain, Mohammad Showkat
Liu, Da
Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
title Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
title_full Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
title_fullStr Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
title_full_unstemmed Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
title_short Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
title_sort involvement of the long noncoding rna h19 in osteogenic differentiation and bone regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819155/
https://www.ncbi.nlm.nih.gov/pubmed/33478579
http://dx.doi.org/10.1186/s13287-021-02149-4
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