Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report

BACKGROUND: KRAS (KRAS proto-oncogene, GTPase; OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS family. This group of proteins is responsible for cell proliferation, differentiation and inhibition of apoptosis. Gain-of-function variants in KRAS are com...

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Detalles Bibliográficos
Autores principales: Blanchard-Rohner, Geraldine, Ragotte, Robert J., Junker, Anne K., Sharma, Mehul, Del Bel, Kate L., Lu, Henry Y., Erdle, Stephanie, Chomyn, Alanna, Gill, Harinder, Tucker, Lori B., Schreiber, Richard A., Rozmus, Jacob, Biggs, Catherine M., Hildebrand, Kyla J., Wu, John, Stockler-Ipsiroglu, Sylvia, Turvey, Stuart E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819237/
https://www.ncbi.nlm.nih.gov/pubmed/33472608
http://dx.doi.org/10.1186/s12887-021-02508-3

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