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PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing
Objectives: To evaluate the mycophenolic acid [MPA, the active form of mycophenolate mofetil (MMF)] pharmacokinetic parameters in relation to clinical response to identify target exposure ranges in pediatric patients with systemic lupus erythematosus (SLE). Methods: This was a retrospective study us...
Autores principales: | Chen, Yewei, Sun, Li, Xu, Hong, Dong, Min, Mizuno, Tomoyuki, Vinks, Alexander A., Brunner, Hermine I., Li, Yifan, Li, Zhiping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819284/ https://www.ncbi.nlm.nih.gov/pubmed/33488386 http://dx.doi.org/10.3389/fphar.2020.605060 |
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