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Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study

The ratio of ∆9-tetrahydrocannabinol (THC) to cannabidiol (CBD) varies widely across cannabis strains. CBD has opposite effects to THC on a variety of cognitive functions, including acute THC-induced memory impairments. However, additional data are needed, especially under naturalistic conditions wi...

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Autores principales: Curran, Tim, Devillez, Hélène, YorkWilliams, Sophie L., Bidwell, L. Cinnamon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819319/
https://www.ncbi.nlm.nih.gov/pubmed/33526107
http://dx.doi.org/10.1186/s42238-020-00034-0
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author Curran, Tim
Devillez, Hélène
YorkWilliams, Sophie L.
Bidwell, L. Cinnamon
author_facet Curran, Tim
Devillez, Hélène
YorkWilliams, Sophie L.
Bidwell, L. Cinnamon
author_sort Curran, Tim
collection PubMed
description The ratio of ∆9-tetrahydrocannabinol (THC) to cannabidiol (CBD) varies widely across cannabis strains. CBD has opposite effects to THC on a variety of cognitive functions, including acute THC-induced memory impairments. However, additional data are needed, especially under naturalistic conditions with higher potency forms of cannabis, commonly available in legal markets. The goal of this study was to collect preliminary data on the acute effects of different THC:CBD ratios on memory testing in a brief verbal recognition task under naturalistic conditions, using legal-market Colorado dispensary products. Thirty-two regular cannabis users consumed cannabis of differing THC and CBD levels purchased from a dispensary and were assessed via blood draw and a verbal recognition memory test both before (pretest) and after (posttest) ad libitum home administration in a mobile laboratory. Memory accuracy decreased as post-use THC blood levels increased (n = 29), whereas performance showed no relationship to CBD blood levels. When controlling for post-use THC blood levels as a covariate, participants using primarily THC-based strains showed significantly worse memory accuracy post-use, whereas subjects using strains containing both THC and CBD showed no differences between pre- and post-use memory performance. Using a brief and sensitive verbal recognition task, our study demonstrated that naturalistic, acute THC use impairs memory in a dose dependent manner, whereas the combination of CBD and THC was not associated with impairment.
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spelling pubmed-78193192021-01-25 Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study Curran, Tim Devillez, Hélène YorkWilliams, Sophie L. Bidwell, L. Cinnamon J Cannabis Res Brief Research Report The ratio of ∆9-tetrahydrocannabinol (THC) to cannabidiol (CBD) varies widely across cannabis strains. CBD has opposite effects to THC on a variety of cognitive functions, including acute THC-induced memory impairments. However, additional data are needed, especially under naturalistic conditions with higher potency forms of cannabis, commonly available in legal markets. The goal of this study was to collect preliminary data on the acute effects of different THC:CBD ratios on memory testing in a brief verbal recognition task under naturalistic conditions, using legal-market Colorado dispensary products. Thirty-two regular cannabis users consumed cannabis of differing THC and CBD levels purchased from a dispensary and were assessed via blood draw and a verbal recognition memory test both before (pretest) and after (posttest) ad libitum home administration in a mobile laboratory. Memory accuracy decreased as post-use THC blood levels increased (n = 29), whereas performance showed no relationship to CBD blood levels. When controlling for post-use THC blood levels as a covariate, participants using primarily THC-based strains showed significantly worse memory accuracy post-use, whereas subjects using strains containing both THC and CBD showed no differences between pre- and post-use memory performance. Using a brief and sensitive verbal recognition task, our study demonstrated that naturalistic, acute THC use impairs memory in a dose dependent manner, whereas the combination of CBD and THC was not associated with impairment. BioMed Central 2020-09-17 /pmc/articles/PMC7819319/ /pubmed/33526107 http://dx.doi.org/10.1186/s42238-020-00034-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Research Report
Curran, Tim
Devillez, Hélène
YorkWilliams, Sophie L.
Bidwell, L. Cinnamon
Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study
title Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study
title_full Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study
title_fullStr Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study
title_full_unstemmed Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study
title_short Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study
title_sort acute effects of naturalistic thc vs. cbd use on recognition memory: a preliminary study
topic Brief Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819319/
https://www.ncbi.nlm.nih.gov/pubmed/33526107
http://dx.doi.org/10.1186/s42238-020-00034-0
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