Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associate...

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Detalles Bibliográficos
Autores principales: Bojang, Abdoulie, Baines, Sarah L, Camara, Bully, Guerillot, Romain, Donovan, Liam, Marqués, Raquel Sánchez, Secka, Ousman, D’Alessandro, Umberto, Bottomley, Christian, Howden, Benjamin P, Roca, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819521/
https://www.ncbi.nlm.nih.gov/pubmed/32445474
http://dx.doi.org/10.1093/cid/ciaa609
Descripción
Sumario:In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942.

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