Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associate...

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Autores principales: Bojang, Abdoulie, Baines, Sarah L, Camara, Bully, Guerillot, Romain, Donovan, Liam, Marqués, Raquel Sánchez, Secka, Ousman, D’Alessandro, Umberto, Bottomley, Christian, Howden, Benjamin P, Roca, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819521/
https://www.ncbi.nlm.nih.gov/pubmed/32445474
http://dx.doi.org/10.1093/cid/ciaa609
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author Bojang, Abdoulie
Baines, Sarah L
Camara, Bully
Guerillot, Romain
Donovan, Liam
Marqués, Raquel Sánchez
Secka, Ousman
D’Alessandro, Umberto
Bottomley, Christian
Howden, Benjamin P
Roca, Anna
author_facet Bojang, Abdoulie
Baines, Sarah L
Camara, Bully
Guerillot, Romain
Donovan, Liam
Marqués, Raquel Sánchez
Secka, Ousman
D’Alessandro, Umberto
Bottomley, Christian
Howden, Benjamin P
Roca, Anna
author_sort Bojang, Abdoulie
collection PubMed
description In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942.
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spelling pubmed-78195212021-01-26 Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial Bojang, Abdoulie Baines, Sarah L Camara, Bully Guerillot, Romain Donovan, Liam Marqués, Raquel Sánchez Secka, Ousman D’Alessandro, Umberto Bottomley, Christian Howden, Benjamin P Roca, Anna Clin Infect Dis Brief Reports In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942. Oxford University Press 2020-05-23 /pmc/articles/PMC7819521/ /pubmed/32445474 http://dx.doi.org/10.1093/cid/ciaa609 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Bojang, Abdoulie
Baines, Sarah L
Camara, Bully
Guerillot, Romain
Donovan, Liam
Marqués, Raquel Sánchez
Secka, Ousman
D’Alessandro, Umberto
Bottomley, Christian
Howden, Benjamin P
Roca, Anna
Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial
title Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial
title_full Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial
title_fullStr Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial
title_full_unstemmed Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial
title_short Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial
title_sort impact of intrapartum oral azithromycin on the acquired macrolide resistome of infants’ nasopharynx: a randomized controlled trial
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819521/
https://www.ncbi.nlm.nih.gov/pubmed/32445474
http://dx.doi.org/10.1093/cid/ciaa609
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