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Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ≈50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, HCM(SMP)), the genetic background is unknown in the other half of the patients (sarcomere mutation-negative, HCM(SMN)). Genotype-s...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819533/ https://www.ncbi.nlm.nih.gov/pubmed/33430602 http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007022 |