Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone delivery ameliorates cardiac dysfunction. As an initial step toward development of ketone therapies, we investigated the effect of chronic...

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Detalles Bibliográficos
Autores principales: Yurista, Salva R., Matsuura, Timothy R., Silljé, Herman H.W., Nijholt, Kirsten T., McDaid, Kendra S., Shewale, Swapnil V., Leone, Teresa C., Newman, John C., Verdin, Eric, van Veldhuisen, Dirk J., de Boer, Rudolf A., Kelly, Daniel P., Westenbrink, B. Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819534/
https://www.ncbi.nlm.nih.gov/pubmed/33356362
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007684

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