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New insights into molecules and pathways of cancer metabolism and therapeutic implications

Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are characterized by unlimited proliferation, transformation and migration, and can destroy normal cells. To meet the needs for cell proliferation and migration, tumor cells acquire molecular materials and energy through...

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Detalles Bibliográficos
Autores principales: Tang, Zhenye, Xu, Zhenhua, Zhu, Xiao, Zhang, Jinfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819563/
https://www.ncbi.nlm.nih.gov/pubmed/33174400
http://dx.doi.org/10.1002/cac2.12112
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author Tang, Zhenye
Xu, Zhenhua
Zhu, Xiao
Zhang, Jinfang
author_facet Tang, Zhenye
Xu, Zhenhua
Zhu, Xiao
Zhang, Jinfang
author_sort Tang, Zhenye
collection PubMed
description Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are characterized by unlimited proliferation, transformation and migration, and can destroy normal cells. To meet the needs for cell proliferation and migration, tumor cells acquire molecular materials and energy through unusual metabolic pathways as their metabolism is more vigorous than that of normal cells. Multiple carcinogenic signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells, including glucose, lipid, and amino acid metabolism. The distinct metabolic signatures of cancer cells reflect that metabolic changes are indispensable for the genesis and development of tumor cells. In this review, we report the unique metabolic alterations in tumor cells which occur through various signaling axes, and present various modalities available for cancer diagnosis and clinical therapy. We further provide suggestions for the development of anti‐tumor therapeutic drugs.
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spelling pubmed-78195632021-01-29 New insights into molecules and pathways of cancer metabolism and therapeutic implications Tang, Zhenye Xu, Zhenhua Zhu, Xiao Zhang, Jinfang Cancer Commun (Lond) Reviews Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are characterized by unlimited proliferation, transformation and migration, and can destroy normal cells. To meet the needs for cell proliferation and migration, tumor cells acquire molecular materials and energy through unusual metabolic pathways as their metabolism is more vigorous than that of normal cells. Multiple carcinogenic signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells, including glucose, lipid, and amino acid metabolism. The distinct metabolic signatures of cancer cells reflect that metabolic changes are indispensable for the genesis and development of tumor cells. In this review, we report the unique metabolic alterations in tumor cells which occur through various signaling axes, and present various modalities available for cancer diagnosis and clinical therapy. We further provide suggestions for the development of anti‐tumor therapeutic drugs. John Wiley and Sons Inc. 2020-11-10 /pmc/articles/PMC7819563/ /pubmed/33174400 http://dx.doi.org/10.1002/cac2.12112 Text en © 2020 The Authors. Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat‐sen University Cancer Center This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Tang, Zhenye
Xu, Zhenhua
Zhu, Xiao
Zhang, Jinfang
New insights into molecules and pathways of cancer metabolism and therapeutic implications
title New insights into molecules and pathways of cancer metabolism and therapeutic implications
title_full New insights into molecules and pathways of cancer metabolism and therapeutic implications
title_fullStr New insights into molecules and pathways of cancer metabolism and therapeutic implications
title_full_unstemmed New insights into molecules and pathways of cancer metabolism and therapeutic implications
title_short New insights into molecules and pathways of cancer metabolism and therapeutic implications
title_sort new insights into molecules and pathways of cancer metabolism and therapeutic implications
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819563/
https://www.ncbi.nlm.nih.gov/pubmed/33174400
http://dx.doi.org/10.1002/cac2.12112
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