Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon growth. This impairs axonal regeneration and causes...

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Detalles Bibliográficos
Autores principales: Wagstaff, Laura J, Gomez-Sanchez, Jose A, Fazal, Shaline V, Otto, Georg W, Kilpatrick, Alastair M, Michael, Kirolos, Wong, Liam YN, Ma, Ki H, Turmaine, Mark, Svaren, John, Gordon, Tessa, Arthur-Farraj, Peter, Velasco-Aviles, Sergio, Cabedo, Hugo, Benito, Cristina, Mirsky, Rhona, Jessen, Kristjan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819709/
https://www.ncbi.nlm.nih.gov/pubmed/33475496
http://dx.doi.org/10.7554/eLife.62232

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