Mitophagy protects β cells from inflammatory damage in diabetes

Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D, respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in impaired bioenergetics and initiation of proapoptotic machinery. Hence, the identification of protective responses to in...

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Detalles Bibliográficos
Autores principales: Sidarala, Vaibhav, Pearson, Gemma L., Parekh, Vishal S., Thompson, Benjamin, Christen, Lisa, Gingerich, Morgan A., Zhu, Jie, Stromer, Tracy, Ren, Jianhua, Reck, Emma C., Chai, Biaoxin, Corbett, John A., Mandrup-Poulsen, Thomas, Satin, Leslie S., Soleimanpour, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819751/
https://www.ncbi.nlm.nih.gov/pubmed/33232298
http://dx.doi.org/10.1172/jci.insight.141138

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