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Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo
Breast cancer is associated with the second highest cancer-associated deaths worldwide. Therefore, understanding the key events that determine breast cancer progression, modulation of the tumor-microenvironment and metastasis, which is the main cause of cancer-associated death, are of great importan...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819848/ https://www.ncbi.nlm.nih.gov/pubmed/33235291 http://dx.doi.org/10.1038/s41388-020-01560-0 |
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author | Attalla, Sherif Taifour, Tarek Bui, Tung Muller, William |
author_facet | Attalla, Sherif Taifour, Tarek Bui, Tung Muller, William |
author_sort | Attalla, Sherif |
collection | PubMed |
description | Breast cancer is associated with the second highest cancer-associated deaths worldwide. Therefore, understanding the key events that determine breast cancer progression, modulation of the tumor-microenvironment and metastasis, which is the main cause of cancer-associated death, are of great importance. The mammary specific polyomavirus middle T antigen overexpression mouse model (MMTV-PyMT), first published in 1992, is the most commonly used genetically engineered mouse model (GEMM) for cancer research. Mammary lesions arising in MMTV-PyMT mice follow similar molecular and histological progression as human breast tumors, making it an invaluable tool for cancer researchers and instrumental in understanding tumor biology. In this review, we will highlight key studies that demonstrate the utility of PyMT derived GEMMs in understanding the molecular basis of breast cancer progression, metastasis and highlight its use as a pre-clinical tool for therapeutic discovery. |
format | Online Article Text |
id | pubmed-7819848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78198482021-01-25 Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo Attalla, Sherif Taifour, Tarek Bui, Tung Muller, William Oncogene Review Article Breast cancer is associated with the second highest cancer-associated deaths worldwide. Therefore, understanding the key events that determine breast cancer progression, modulation of the tumor-microenvironment and metastasis, which is the main cause of cancer-associated death, are of great importance. The mammary specific polyomavirus middle T antigen overexpression mouse model (MMTV-PyMT), first published in 1992, is the most commonly used genetically engineered mouse model (GEMM) for cancer research. Mammary lesions arising in MMTV-PyMT mice follow similar molecular and histological progression as human breast tumors, making it an invaluable tool for cancer researchers and instrumental in understanding tumor biology. In this review, we will highlight key studies that demonstrate the utility of PyMT derived GEMMs in understanding the molecular basis of breast cancer progression, metastasis and highlight its use as a pre-clinical tool for therapeutic discovery. Nature Publishing Group UK 2020-11-24 2021 /pmc/articles/PMC7819848/ /pubmed/33235291 http://dx.doi.org/10.1038/s41388-020-01560-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Attalla, Sherif Taifour, Tarek Bui, Tung Muller, William Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo |
title | Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo |
title_full | Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo |
title_fullStr | Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo |
title_full_unstemmed | Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo |
title_short | Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo |
title_sort | insights from transgenic mouse models of pymt-induced breast cancer: recapitulating human breast cancer progression in vivo |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819848/ https://www.ncbi.nlm.nih.gov/pubmed/33235291 http://dx.doi.org/10.1038/s41388-020-01560-0 |
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