Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk

Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds directly to integrin β-chain cytoplasmic domains. Here, we developed a high-throughput screen to identify small molecule inhibitors of the Syk-int...

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Detalles Bibliográficos
Autores principales: Bakthavatsalam, Deenadayalan, Craft, John W., Kazansky, Anna, Nguyen, Nghi, Bae, Goeun, Caivano, Amy R., Gundlach, C. William, Aslam, Asra, Ali, Safa, Gupta, Shashikant, Lin, Sophie Y., Parthiban, Hema D., Vanderslice, Peter, Stephan, Clifford C., Woodside, Darren G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819857/
https://www.ncbi.nlm.nih.gov/pubmed/33488575
http://dx.doi.org/10.3389/fimmu.2020.575085

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