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Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers

BACKGROUND AND AIMS: Photochemical internalization (PCI) is a technology for inducing release of endocytosed antigens into the cell cytosol via a light-induced process. Preclinical experiments have shown that PCI improves MHC class I antigen presentation, resulting in strongly enhanced CD8+ T-cell r...

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Detalles Bibliográficos
Autores principales:	Otterhaug, Tone, Janetzki, Sylvia, Welters, Marij J. P., Håkerud, Monika, Nedberg, Anne Grete, Edwards, Victoria Tudor, Boekestijn, Sanne, Loof, Nikki M., Selbo, Pål Kristian, Olivecrona, Hans, van der Burg, Sjoerd H., Høgset, Anders
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819858/ https://www.ncbi.nlm.nih.gov/pubmed/33488576 http://dx.doi.org/10.3389/fimmu.2020.576756

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