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Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses

Emerging and re-emerging RNA viruses pose significant public health, economic, and societal burdens. Hantaviruses (genus Orthohantavirus, family Hantaviridae, order Bunyavirales) are enveloped, negative-sense, single-stranded, tripartite RNA viruses that are emerging zoonotic pathogens harbored by s...

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Autores principales: Kim, Won-Keun, Cho, Seungchan, Lee, Seung-Ho, No, Jin Sun, Lee, Geum-Young, Park, Kyungmin, Lee, Daesang, Jeong, Seong Tae, Song, Jin-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819890/
https://www.ncbi.nlm.nih.gov/pubmed/33489927
http://dx.doi.org/10.3389/fcimb.2020.532388
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author Kim, Won-Keun
Cho, Seungchan
Lee, Seung-Ho
No, Jin Sun
Lee, Geum-Young
Park, Kyungmin
Lee, Daesang
Jeong, Seong Tae
Song, Jin-Won
author_facet Kim, Won-Keun
Cho, Seungchan
Lee, Seung-Ho
No, Jin Sun
Lee, Geum-Young
Park, Kyungmin
Lee, Daesang
Jeong, Seong Tae
Song, Jin-Won
author_sort Kim, Won-Keun
collection PubMed
description Emerging and re-emerging RNA viruses pose significant public health, economic, and societal burdens. Hantaviruses (genus Orthohantavirus, family Hantaviridae, order Bunyavirales) are enveloped, negative-sense, single-stranded, tripartite RNA viruses that are emerging zoonotic pathogens harbored by small mammals such as rodents, bats, moles, and shrews. Orthohantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome in humans (HCPS). Active targeted surveillance has elucidated high-resolution phylogeographic relationships between patient- and rodent-derived orthohantavirus genome sequences and identified the infection source by temporally and spatially tracking viral genomes. Active surveillance of patients with HFRS entails 1) recovering whole-genome sequences of Hantaan virus (HTNV) using amplicon (multiplex PCR-based) next-generation sequencing, 2) tracing the putative infection site of a patient by administering an epidemiological questionnaire, and 3) collecting HTNV-positive rodents using targeted rodent trapping. Moreover, viral genome tracking has been recently performed to rapidly and precisely characterize an outbreak from the emerging virus. Here, we reviewed genomic epidemiological and active surveillance data for determining the emergence of zoonotic RNA viruses based on viral genomic sequences obtained from patients and natural reservoirs. This review highlights the recent studies on tracking viral genomes for identifying and characterizing emerging viral outbreaks worldwide. We believe that active surveillance is an effective method for identifying rodent-borne orthohantavirus infection sites, and this report provides insights into disease mitigation and preparedness for managing emerging viral outbreaks.
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spelling pubmed-78198902021-01-23 Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses Kim, Won-Keun Cho, Seungchan Lee, Seung-Ho No, Jin Sun Lee, Geum-Young Park, Kyungmin Lee, Daesang Jeong, Seong Tae Song, Jin-Won Front Cell Infect Microbiol Cellular and Infection Microbiology Emerging and re-emerging RNA viruses pose significant public health, economic, and societal burdens. Hantaviruses (genus Orthohantavirus, family Hantaviridae, order Bunyavirales) are enveloped, negative-sense, single-stranded, tripartite RNA viruses that are emerging zoonotic pathogens harbored by small mammals such as rodents, bats, moles, and shrews. Orthohantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome in humans (HCPS). Active targeted surveillance has elucidated high-resolution phylogeographic relationships between patient- and rodent-derived orthohantavirus genome sequences and identified the infection source by temporally and spatially tracking viral genomes. Active surveillance of patients with HFRS entails 1) recovering whole-genome sequences of Hantaan virus (HTNV) using amplicon (multiplex PCR-based) next-generation sequencing, 2) tracing the putative infection site of a patient by administering an epidemiological questionnaire, and 3) collecting HTNV-positive rodents using targeted rodent trapping. Moreover, viral genome tracking has been recently performed to rapidly and precisely characterize an outbreak from the emerging virus. Here, we reviewed genomic epidemiological and active surveillance data for determining the emergence of zoonotic RNA viruses based on viral genomic sequences obtained from patients and natural reservoirs. This review highlights the recent studies on tracking viral genomes for identifying and characterizing emerging viral outbreaks worldwide. We believe that active surveillance is an effective method for identifying rodent-borne orthohantavirus infection sites, and this report provides insights into disease mitigation and preparedness for managing emerging viral outbreaks. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7819890/ /pubmed/33489927 http://dx.doi.org/10.3389/fcimb.2020.532388 Text en Copyright © 2021 Kim, Cho, Lee, No, Lee, Park, Lee, Jeong and Song http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Kim, Won-Keun
Cho, Seungchan
Lee, Seung-Ho
No, Jin Sun
Lee, Geum-Young
Park, Kyungmin
Lee, Daesang
Jeong, Seong Tae
Song, Jin-Won
Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses
title Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses
title_full Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses
title_fullStr Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses
title_full_unstemmed Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses
title_short Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses
title_sort genomic epidemiology and active surveillance to investigate outbreaks of hantaviruses
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819890/
https://www.ncbi.nlm.nih.gov/pubmed/33489927
http://dx.doi.org/10.3389/fcimb.2020.532388
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