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Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan

AIM: Studies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited. METHODS: In this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same data...

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Autores principales: Su, Fu-Hsiung, Bai, Chyi-Huey, Le, Thi Nga, Muo, Chih-Hsin, Chang, Shih-Ni, Te, Arlene, Sung, Fung-Chang, Yeh, Chih-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819899/
https://www.ncbi.nlm.nih.gov/pubmed/33489873
http://dx.doi.org/10.3389/fonc.2020.561420
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author Su, Fu-Hsiung
Bai, Chyi-Huey
Le, Thi Nga
Muo, Chih-Hsin
Chang, Shih-Ni
Te, Arlene
Sung, Fung-Chang
Yeh, Chih-Ching
author_facet Su, Fu-Hsiung
Bai, Chyi-Huey
Le, Thi Nga
Muo, Chih-Hsin
Chang, Shih-Ni
Te, Arlene
Sung, Fung-Chang
Yeh, Chih-Ching
author_sort Su, Fu-Hsiung
collection PubMed
description AIM: Studies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited. METHODS: In this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases. RESULTS: Results of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08–1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70. CONCLUSIONS: Our findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients.
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spelling pubmed-78198992021-01-23 Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan Su, Fu-Hsiung Bai, Chyi-Huey Le, Thi Nga Muo, Chih-Hsin Chang, Shih-Ni Te, Arlene Sung, Fung-Chang Yeh, Chih-Ching Front Oncol Oncology AIM: Studies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited. METHODS: In this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases. RESULTS: Results of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08–1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70. CONCLUSIONS: Our findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7819899/ /pubmed/33489873 http://dx.doi.org/10.3389/fonc.2020.561420 Text en Copyright © 2021 Su, Bai, Le, Muo, Chang, Te, Sung and Yeh http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Su, Fu-Hsiung
Bai, Chyi-Huey
Le, Thi Nga
Muo, Chih-Hsin
Chang, Shih-Ni
Te, Arlene
Sung, Fung-Chang
Yeh, Chih-Ching
Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
title Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
title_full Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
title_fullStr Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
title_full_unstemmed Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
title_short Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
title_sort patients with chronic hepatitis c virus infection are at an increased risk of colorectal cancer: a nationwide population-based case-control study in taiwan
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819899/
https://www.ncbi.nlm.nih.gov/pubmed/33489873
http://dx.doi.org/10.3389/fonc.2020.561420
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