Cargando…
Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings
Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investigate whether the position of recording sites on the silicon sh...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819990/ https://www.ncbi.nlm.nih.gov/pubmed/33479289 http://dx.doi.org/10.1038/s41598-021-81127-5 |
_version_ | 1783639113853829120 |
---|---|
author | Fiáth, Richárd Meszéna, Domokos Somogyvári, Zoltán Boda, Mihály Barthó, Péter Ruther, Patrick Ulbert, István |
author_facet | Fiáth, Richárd Meszéna, Domokos Somogyvári, Zoltán Boda, Mihály Barthó, Péter Ruther, Patrick Ulbert, István |
author_sort | Fiáth, Richárd |
collection | PubMed |
description | Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investigate whether the position of recording sites on the silicon shank might affect the quality of the recorded neural signal in acute experiments. Neural recordings obtained with five different types of high-density, single-shank, planar silicon probes from anesthetized rats were analyzed. Wideband data were filtered to extract spiking activity, then the amplitude distribution of samples and quantitative properties of the recorded brain activity (single unit yield, spike amplitude and isolation distance) were compared between sites located at different positions of the silicon shank, focusing particularly on edge and center sites. Edge sites outperformed center sites: for all five probe types there was a significant difference in the signal power computed from the amplitude distributions, and edge sites recorded significantly more large amplitude samples both in the positive and negative range. Although the single unit yield was similar between site positions, the difference in spike amplitudes was noticeable in the range corresponding to high-amplitude spikes. Furthermore, the advantage of edge sites slightly decreased with decreasing shank width. Our results might aid the design of novel neural implants in enhancing their recording performance by identifying more efficient recording site placements. |
format | Online Article Text |
id | pubmed-7819990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78199902021-01-22 Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings Fiáth, Richárd Meszéna, Domokos Somogyvári, Zoltán Boda, Mihály Barthó, Péter Ruther, Patrick Ulbert, István Sci Rep Article Multisite, silicon-based probes are widely used tools to record the electrical activity of neuronal populations. Several physical features of these devices are designed to improve their recording performance. Here, our goal was to investigate whether the position of recording sites on the silicon shank might affect the quality of the recorded neural signal in acute experiments. Neural recordings obtained with five different types of high-density, single-shank, planar silicon probes from anesthetized rats were analyzed. Wideband data were filtered to extract spiking activity, then the amplitude distribution of samples and quantitative properties of the recorded brain activity (single unit yield, spike amplitude and isolation distance) were compared between sites located at different positions of the silicon shank, focusing particularly on edge and center sites. Edge sites outperformed center sites: for all five probe types there was a significant difference in the signal power computed from the amplitude distributions, and edge sites recorded significantly more large amplitude samples both in the positive and negative range. Although the single unit yield was similar between site positions, the difference in spike amplitudes was noticeable in the range corresponding to high-amplitude spikes. Furthermore, the advantage of edge sites slightly decreased with decreasing shank width. Our results might aid the design of novel neural implants in enhancing their recording performance by identifying more efficient recording site placements. Nature Publishing Group UK 2021-01-21 /pmc/articles/PMC7819990/ /pubmed/33479289 http://dx.doi.org/10.1038/s41598-021-81127-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Fiáth, Richárd Meszéna, Domokos Somogyvári, Zoltán Boda, Mihály Barthó, Péter Ruther, Patrick Ulbert, István Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
title | Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
title_full | Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
title_fullStr | Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
title_full_unstemmed | Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
title_short | Recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
title_sort | recording site placement on planar silicon-based probes affects signal quality in acute neuronal recordings |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819990/ https://www.ncbi.nlm.nih.gov/pubmed/33479289 http://dx.doi.org/10.1038/s41598-021-81127-5 |
work_keys_str_mv | AT fiathrichard recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings AT meszenadomokos recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings AT somogyvarizoltan recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings AT bodamihaly recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings AT barthopeter recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings AT rutherpatrick recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings AT ulbertistvan recordingsiteplacementonplanarsiliconbasedprobesaffectssignalqualityinacuteneuronalrecordings |