Cargando…

Platelet Membrane Receptor Proteolysis: Implications for Platelet Function

The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different ori...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Jiayu, Heemskerk, Johan W. M., Baaten, Constance C. F. M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820117/
https://www.ncbi.nlm.nih.gov/pubmed/33490118
http://dx.doi.org/10.3389/fcvm.2020.608391
_version_ 1783639137847345152
author Wu, Jiayu
Heemskerk, Johan W. M.
Baaten, Constance C. F. M. J.
author_facet Wu, Jiayu
Heemskerk, Johan W. M.
Baaten, Constance C. F. M. J.
author_sort Wu, Jiayu
collection PubMed
description The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. We provide a comprehensive overview of the proteases acting on the platelet membrane. We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. The review focuses on coagulation-related proteases, plasmin, matrix metalloproteinases, ADAM(TS) isoforms, cathepsins, caspases, and calpains. We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations.
format Online
Article
Text
id pubmed-7820117
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78201172021-01-23 Platelet Membrane Receptor Proteolysis: Implications for Platelet Function Wu, Jiayu Heemskerk, Johan W. M. Baaten, Constance C. F. M. J. Front Cardiovasc Med Cardiovascular Medicine The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. We provide a comprehensive overview of the proteases acting on the platelet membrane. We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. The review focuses on coagulation-related proteases, plasmin, matrix metalloproteinases, ADAM(TS) isoforms, cathepsins, caspases, and calpains. We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7820117/ /pubmed/33490118 http://dx.doi.org/10.3389/fcvm.2020.608391 Text en Copyright © 2021 Wu, Heemskerk and Baaten. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wu, Jiayu
Heemskerk, Johan W. M.
Baaten, Constance C. F. M. J.
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
title Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
title_full Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
title_fullStr Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
title_full_unstemmed Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
title_short Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
title_sort platelet membrane receptor proteolysis: implications for platelet function
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820117/
https://www.ncbi.nlm.nih.gov/pubmed/33490118
http://dx.doi.org/10.3389/fcvm.2020.608391
work_keys_str_mv AT wujiayu plateletmembranereceptorproteolysisimplicationsforplateletfunction
AT heemskerkjohanwm plateletmembranereceptorproteolysisimplicationsforplateletfunction
AT baatenconstancecfmj plateletmembranereceptorproteolysisimplicationsforplateletfunction