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Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells

Doublecortin-like kinase 1 (DCLK1)-positive pancreatic cancer stem cells develop at a precancerous stage and may contribute to the lack of efficacy of pancreatic cancer therapy. Although PanIN cells express oncogenic KRas and have an increased activity of epidermal growth factor receptor (EGFR), we...

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Detalles Bibliográficos
Autores principales:	Fleming Martinez, Alicia K., Döppler, Heike R., Bastea, Ligia I., Edenfield, Brandy, Patel, Tushar, Leitges, Michael, Liou, Geou-Yarh, Storz, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820128/ https://www.ncbi.nlm.nih.gov/pubmed/33521594 http://dx.doi.org/10.1016/j.isci.2020.102019

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