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An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub(6)
The 26S proteasome is specialized for regulated protein degradation. It is formed by a regulatory particle (RP) that recognizes ubiquitinated substrates and caps a hollow cylindrical core particle (CP) where substrates are proteolyzed. Structural heterogeneity caused by dynamics makes it challenging...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820132/ https://www.ncbi.nlm.nih.gov/pubmed/33521680 http://dx.doi.org/10.1016/j.xpro.2020.100278 |