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Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex

Adolescence is a time of intense cortical development and a period of heightened sensitivity to insult. To determine how sex affects the short- and long-term outcomes of early-adolescent stress exposure, we subjected prepubescent (postnatal day 30) male and female mice to repeated multiple concurren...

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Detalles Bibliográficos
Autores principales: Fariborzi, Mona, Park, Soo Bin, Ozgur, Ali, Lur, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820135/
https://www.ncbi.nlm.nih.gov/pubmed/33521171
http://dx.doi.org/10.1016/j.ynstr.2021.100295
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author Fariborzi, Mona
Park, Soo Bin
Ozgur, Ali
Lur, Gyorgy
author_facet Fariborzi, Mona
Park, Soo Bin
Ozgur, Ali
Lur, Gyorgy
author_sort Fariborzi, Mona
collection PubMed
description Adolescence is a time of intense cortical development and a period of heightened sensitivity to insult. To determine how sex affects the short- and long-term outcomes of early-adolescent stress exposure, we subjected prepubescent (postnatal day 30) male and female mice to repeated multiple concurrent stressors (RMS). In the posterior parietal cortex (PPC), RMS caused the elimination of excitatory synapses in deeper layers while inhibitory synapse density was predominantly diminished in superficial layers. These short-term effects coincided with reduced visuo-spatial working memory and were similar in both sexes. The loss of excitatory synapses and impaired working memory persisted in males past a 30-day recovery period. In contrast, we observed a remarkable recovery of excitatory transmission and behavioral performance in females. Inhibitory synapse density recovered in both sexes. We have also observed a late onset anxiety phenotype in RMS exposed females that was absent in males. Overall, our results indicate that there are marked sex differences in the long-term effects of prepubescent stress on cortical synapses and behavior.
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spelling pubmed-78201352021-01-29 Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex Fariborzi, Mona Park, Soo Bin Ozgur, Ali Lur, Gyorgy Neurobiol Stress Original Research Article Adolescence is a time of intense cortical development and a period of heightened sensitivity to insult. To determine how sex affects the short- and long-term outcomes of early-adolescent stress exposure, we subjected prepubescent (postnatal day 30) male and female mice to repeated multiple concurrent stressors (RMS). In the posterior parietal cortex (PPC), RMS caused the elimination of excitatory synapses in deeper layers while inhibitory synapse density was predominantly diminished in superficial layers. These short-term effects coincided with reduced visuo-spatial working memory and were similar in both sexes. The loss of excitatory synapses and impaired working memory persisted in males past a 30-day recovery period. In contrast, we observed a remarkable recovery of excitatory transmission and behavioral performance in females. Inhibitory synapse density recovered in both sexes. We have also observed a late onset anxiety phenotype in RMS exposed females that was absent in males. Overall, our results indicate that there are marked sex differences in the long-term effects of prepubescent stress on cortical synapses and behavior. Elsevier 2021-01-13 /pmc/articles/PMC7820135/ /pubmed/33521171 http://dx.doi.org/10.1016/j.ynstr.2021.100295 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Fariborzi, Mona
Park, Soo Bin
Ozgur, Ali
Lur, Gyorgy
Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
title Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
title_full Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
title_fullStr Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
title_full_unstemmed Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
title_short Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
title_sort sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820135/
https://www.ncbi.nlm.nih.gov/pubmed/33521171
http://dx.doi.org/10.1016/j.ynstr.2021.100295
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