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Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women

25-Hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) need to be bound to carrier proteins to be transported to their target cells. The majority of either 25OHD or 1,25(OH)(2)D is bound to vitamin D-binding protein (DBP), a smaller fraction is bound to albumin and only very small am...

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Autores principales: Tsuprykov, Oleg, Elitok, Saban, Buse, Claudia, Chu, Chang, Krämer, Bernhard Karl, Hocher, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820257/
https://www.ncbi.nlm.nih.gov/pubmed/33479299
http://dx.doi.org/10.1038/s41598-021-81452-9
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author Tsuprykov, Oleg
Elitok, Saban
Buse, Claudia
Chu, Chang
Krämer, Bernhard Karl
Hocher, Berthold
author_facet Tsuprykov, Oleg
Elitok, Saban
Buse, Claudia
Chu, Chang
Krämer, Bernhard Karl
Hocher, Berthold
author_sort Tsuprykov, Oleg
collection PubMed
description 25-Hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) need to be bound to carrier proteins to be transported to their target cells. The majority of either 25OHD or 1,25(OH)(2)D is bound to vitamin D-binding protein (DBP), a smaller fraction is bound to albumin and only very small amounts of 25OHD or 1,25(OH)(2)D are free. Albumin-bound 25OHD or 1,25(OH)(2)D is relatively easily available after dissociation from albumin. Thus, the sum of free and albumin-bound forms is called bioavailable 25OHD and bioavailable 1,25(OH)(2)D. Total 25OHD and 1,25(OH)(2)D are defined as the sum of free, albumin-bound and DBP-bound 25OHD and 1,25(OH)(2)D, respectively. This cross-sectional study in 427 pregnant women compared the correlation of the six vitamin D compounds with biomarkers of bone health, lipid metabolism, kidney function, endocrine parameters, and group B water-soluble vitamins. Among the 25OHD metabolites analysed, total 1,25(OH)(2)D showed clearly the best correlation with calcium, bone-specific alkaline phosphatase, adiponectin, LDL, HDL, urea, thyroxine, and group B water-soluble vitamins. When comparing the three 25OHD metabolites, both free 25OHD and bioavailable 25OHD showed overall good correlations with calcium, bone-specific alkaline phosphatase, adiponectin, LDL, HDL, urea, thyroxine, triiodothyronine, and group B water-soluble vitamins, The correlations of 1,25(OH)(2)D and 25OHD metabolites went always in opposite directions. Only PTH correlates always inversely with all six vitamin D compounds. In conclusion, free 25(OH)D and bioavailable 25(OH)D are more precise determinants of the vitamin D status than total 25(OH)D in normal pregnancy, whereas total 1,25(OH)(2)D is superior to free and bioavailable 1,25(OH)(2)D. Except for PTH, correlations of 25(OH)D and 1,25(OH)(2)D metabolites with typical clinical chemistry readouts go in opposite directions.
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spelling pubmed-78202572021-01-22 Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women Tsuprykov, Oleg Elitok, Saban Buse, Claudia Chu, Chang Krämer, Bernhard Karl Hocher, Berthold Sci Rep Article 25-Hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) need to be bound to carrier proteins to be transported to their target cells. The majority of either 25OHD or 1,25(OH)(2)D is bound to vitamin D-binding protein (DBP), a smaller fraction is bound to albumin and only very small amounts of 25OHD or 1,25(OH)(2)D are free. Albumin-bound 25OHD or 1,25(OH)(2)D is relatively easily available after dissociation from albumin. Thus, the sum of free and albumin-bound forms is called bioavailable 25OHD and bioavailable 1,25(OH)(2)D. Total 25OHD and 1,25(OH)(2)D are defined as the sum of free, albumin-bound and DBP-bound 25OHD and 1,25(OH)(2)D, respectively. This cross-sectional study in 427 pregnant women compared the correlation of the six vitamin D compounds with biomarkers of bone health, lipid metabolism, kidney function, endocrine parameters, and group B water-soluble vitamins. Among the 25OHD metabolites analysed, total 1,25(OH)(2)D showed clearly the best correlation with calcium, bone-specific alkaline phosphatase, adiponectin, LDL, HDL, urea, thyroxine, and group B water-soluble vitamins. When comparing the three 25OHD metabolites, both free 25OHD and bioavailable 25OHD showed overall good correlations with calcium, bone-specific alkaline phosphatase, adiponectin, LDL, HDL, urea, thyroxine, triiodothyronine, and group B water-soluble vitamins, The correlations of 1,25(OH)(2)D and 25OHD metabolites went always in opposite directions. Only PTH correlates always inversely with all six vitamin D compounds. In conclusion, free 25(OH)D and bioavailable 25(OH)D are more precise determinants of the vitamin D status than total 25(OH)D in normal pregnancy, whereas total 1,25(OH)(2)D is superior to free and bioavailable 1,25(OH)(2)D. Except for PTH, correlations of 25(OH)D and 1,25(OH)(2)D metabolites with typical clinical chemistry readouts go in opposite directions. Nature Publishing Group UK 2021-01-21 /pmc/articles/PMC7820257/ /pubmed/33479299 http://dx.doi.org/10.1038/s41598-021-81452-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tsuprykov, Oleg
Elitok, Saban
Buse, Claudia
Chu, Chang
Krämer, Bernhard Karl
Hocher, Berthold
Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
title Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
title_full Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
title_fullStr Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
title_full_unstemmed Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
title_short Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
title_sort opposite correlation of 25-hydroxy-vitamin d- and 1,25-dihydroxy-vitamin d-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820257/
https://www.ncbi.nlm.nih.gov/pubmed/33479299
http://dx.doi.org/10.1038/s41598-021-81452-9
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