Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery

Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused ultrasound (MRIgFUS) to temporarily and locally permeabilize the blood–brain barrier. Vector and promoter selection can provide neuronal expression in...

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Detalles Bibliográficos
Autores principales: Weber-Adrian, Danielle, Kofoed, Rikke Hahn, Silburt, Joseph, Noroozian, Zeinab, Shah, Kairavi, Burgess, Alison, Rideout, Shawna, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820310/
https://www.ncbi.nlm.nih.gov/pubmed/33479314
http://dx.doi.org/10.1038/s41598-021-81046-5

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