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Clearing Traffic Jams During Protein Translocation Across Membranes
Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations. It is well established that protein biogenes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820333/ https://www.ncbi.nlm.nih.gov/pubmed/33490075 http://dx.doi.org/10.3389/fcell.2020.610689 |
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author | Wang, Lihui Ye, Yihong |
author_facet | Wang, Lihui Ye, Yihong |
author_sort | Wang, Lihui |
collection | PubMed |
description | Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations. It is well established that protein biogenesis is tightly linked to various protein quality control processes, which monitor errors in protein folding, modification, and localization. However, little is known about how cells cope with translocation defective polypeptides that clog translocation channels (translocons) during protein translocation. This review summarizes recent studies, which collectively reveal a set of translocon-associated quality control strategies for eliminating polypeptides stuck in protein-conducting channels in the endoplasmic reticulum and mitochondria. |
format | Online Article Text |
id | pubmed-7820333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78203332021-01-23 Clearing Traffic Jams During Protein Translocation Across Membranes Wang, Lihui Ye, Yihong Front Cell Dev Biol Cell and Developmental Biology Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations. It is well established that protein biogenesis is tightly linked to various protein quality control processes, which monitor errors in protein folding, modification, and localization. However, little is known about how cells cope with translocation defective polypeptides that clog translocation channels (translocons) during protein translocation. This review summarizes recent studies, which collectively reveal a set of translocon-associated quality control strategies for eliminating polypeptides stuck in protein-conducting channels in the endoplasmic reticulum and mitochondria. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7820333/ /pubmed/33490075 http://dx.doi.org/10.3389/fcell.2020.610689 Text en Copyright © 2021 Wang and Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wang, Lihui Ye, Yihong Clearing Traffic Jams During Protein Translocation Across Membranes |
title | Clearing Traffic Jams During Protein Translocation Across Membranes |
title_full | Clearing Traffic Jams During Protein Translocation Across Membranes |
title_fullStr | Clearing Traffic Jams During Protein Translocation Across Membranes |
title_full_unstemmed | Clearing Traffic Jams During Protein Translocation Across Membranes |
title_short | Clearing Traffic Jams During Protein Translocation Across Membranes |
title_sort | clearing traffic jams during protein translocation across membranes |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820333/ https://www.ncbi.nlm.nih.gov/pubmed/33490075 http://dx.doi.org/10.3389/fcell.2020.610689 |
work_keys_str_mv | AT wanglihui clearingtrafficjamsduringproteintranslocationacrossmembranes AT yeyihong clearingtrafficjamsduringproteintranslocationacrossmembranes |