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Clearing Traffic Jams During Protein Translocation Across Membranes

Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations. It is well established that protein biogenes...

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Detalles Bibliográficos
Autores principales: Wang, Lihui, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820333/
https://www.ncbi.nlm.nih.gov/pubmed/33490075
http://dx.doi.org/10.3389/fcell.2020.610689
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author Wang, Lihui
Ye, Yihong
author_facet Wang, Lihui
Ye, Yihong
author_sort Wang, Lihui
collection PubMed
description Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations. It is well established that protein biogenesis is tightly linked to various protein quality control processes, which monitor errors in protein folding, modification, and localization. However, little is known about how cells cope with translocation defective polypeptides that clog translocation channels (translocons) during protein translocation. This review summarizes recent studies, which collectively reveal a set of translocon-associated quality control strategies for eliminating polypeptides stuck in protein-conducting channels in the endoplasmic reticulum and mitochondria.
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spelling pubmed-78203332021-01-23 Clearing Traffic Jams During Protein Translocation Across Membranes Wang, Lihui Ye, Yihong Front Cell Dev Biol Cell and Developmental Biology Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations. It is well established that protein biogenesis is tightly linked to various protein quality control processes, which monitor errors in protein folding, modification, and localization. However, little is known about how cells cope with translocation defective polypeptides that clog translocation channels (translocons) during protein translocation. This review summarizes recent studies, which collectively reveal a set of translocon-associated quality control strategies for eliminating polypeptides stuck in protein-conducting channels in the endoplasmic reticulum and mitochondria. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7820333/ /pubmed/33490075 http://dx.doi.org/10.3389/fcell.2020.610689 Text en Copyright © 2021 Wang and Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Lihui
Ye, Yihong
Clearing Traffic Jams During Protein Translocation Across Membranes
title Clearing Traffic Jams During Protein Translocation Across Membranes
title_full Clearing Traffic Jams During Protein Translocation Across Membranes
title_fullStr Clearing Traffic Jams During Protein Translocation Across Membranes
title_full_unstemmed Clearing Traffic Jams During Protein Translocation Across Membranes
title_short Clearing Traffic Jams During Protein Translocation Across Membranes
title_sort clearing traffic jams during protein translocation across membranes
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820333/
https://www.ncbi.nlm.nih.gov/pubmed/33490075
http://dx.doi.org/10.3389/fcell.2020.610689
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