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Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life

Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and ac...

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Autores principales: Chaguza, Chrispin, Senghore, Madikay, Bojang, Ebrima, Lo, Stephanie W., Ebruke, Chinelo, Gladstone, Rebecca A., Tientcheu, Peggy-Estelle, Bancroft, Rowan E., Worwui, Archibald, Foster-Nyarko, Ebenezer, Ceesay, Fatima, Okoi, Catherine, McGee, Lesley, Klugman, Keith P., Breiman, Robert F., Barer, Michael R., Adegbola, Richard A., Antonio, Martin, Bentley, Stephen D., Kwambana-Adams, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820366/
https://www.ncbi.nlm.nih.gov/pubmed/33489998
http://dx.doi.org/10.3389/fped.2020.587730
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author Chaguza, Chrispin
Senghore, Madikay
Bojang, Ebrima
Lo, Stephanie W.
Ebruke, Chinelo
Gladstone, Rebecca A.
Tientcheu, Peggy-Estelle
Bancroft, Rowan E.
Worwui, Archibald
Foster-Nyarko, Ebenezer
Ceesay, Fatima
Okoi, Catherine
McGee, Lesley
Klugman, Keith P.
Breiman, Robert F.
Barer, Michael R.
Adegbola, Richard A.
Antonio, Martin
Bentley, Stephen D.
Kwambana-Adams, Brenda A.
author_facet Chaguza, Chrispin
Senghore, Madikay
Bojang, Ebrima
Lo, Stephanie W.
Ebruke, Chinelo
Gladstone, Rebecca A.
Tientcheu, Peggy-Estelle
Bancroft, Rowan E.
Worwui, Archibald
Foster-Nyarko, Ebenezer
Ceesay, Fatima
Okoi, Catherine
McGee, Lesley
Klugman, Keith P.
Breiman, Robert F.
Barer, Michael R.
Adegbola, Richard A.
Antonio, Martin
Bentley, Stephen D.
Kwambana-Adams, Brenda A.
author_sort Chaguza, Chrispin
collection PubMed
description Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines.
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spelling pubmed-78203662021-01-23 Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life Chaguza, Chrispin Senghore, Madikay Bojang, Ebrima Lo, Stephanie W. Ebruke, Chinelo Gladstone, Rebecca A. Tientcheu, Peggy-Estelle Bancroft, Rowan E. Worwui, Archibald Foster-Nyarko, Ebenezer Ceesay, Fatima Okoi, Catherine McGee, Lesley Klugman, Keith P. Breiman, Robert F. Barer, Michael R. Adegbola, Richard A. Antonio, Martin Bentley, Stephen D. Kwambana-Adams, Brenda A. Front Pediatr Pediatrics Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7820366/ /pubmed/33489998 http://dx.doi.org/10.3389/fped.2020.587730 Text en Copyright © 2021 Chaguza, Senghore, Bojang, Lo, Ebruke, Gladstone, Tientcheu, Bancroft, Worwui, Foster-Nyarko, Ceesay, Okoi, McGee, Klugman, Breiman, Barer, Adegbola, Antonio, Bentley and Kwambana-Adams. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Chaguza, Chrispin
Senghore, Madikay
Bojang, Ebrima
Lo, Stephanie W.
Ebruke, Chinelo
Gladstone, Rebecca A.
Tientcheu, Peggy-Estelle
Bancroft, Rowan E.
Worwui, Archibald
Foster-Nyarko, Ebenezer
Ceesay, Fatima
Okoi, Catherine
McGee, Lesley
Klugman, Keith P.
Breiman, Robert F.
Barer, Michael R.
Adegbola, Richard A.
Antonio, Martin
Bentley, Stephen D.
Kwambana-Adams, Brenda A.
Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
title Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
title_full Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
title_fullStr Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
title_full_unstemmed Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
title_short Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
title_sort carriage dynamics of pneumococcal serotypes in naturally colonized infants in a rural african setting during the first year of life
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820366/
https://www.ncbi.nlm.nih.gov/pubmed/33489998
http://dx.doi.org/10.3389/fped.2020.587730
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